Gene
gstm.1
- ID
- ZDB-GENE-030911-2
- Name
- glutathione S-transferase mu, tandem duplicate 1
- Symbol
- gstm.1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Enables glutathione transferase activity. Predicted to be involved in glutathione metabolic process. Is expressed in several structures, including alar plate midbrain region; brain; gill; pectoral fin bud; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung disease (multiple). Orthologous to several human genes including GSTM3 (glutathione S-transferase mu 3).
- Genome Resources
- Note
-
Orthology for gstm is complicated due to tandem duplications in the human genome which results in gstm being syntenic to GSTM1, GSTM2, GSTM3,GSTM4, GSTM5.
- Comparative Information
-
- All Expression Data
- 9 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb760 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004045 | Glutathione S-transferase, N-terminal |
| Domain | IPR004046 | Glutathione S-transferase, C-terminal |
| Domain | IPR010987 | Glutathione S-transferase, C-terminal-like |
| Family | IPR003081 | Glutathione S-transferase, Mu class |
| Family | IPR040079 | Glutathione transferase family |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Glutathione S-transferase, C-terminal | Glutathione S-transferase, C-terminal domain superfamily | Glutathione S-transferase, C-terminal-like | Glutathione S-transferase, Mu class | Glutathione S-transferase, N-terminal | Glutathione S-transferase superfamily | Glutathione transferase family | Thioredoxin-like superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6PFJ6 | InterPro | 219 |
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- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gstm.1-201
(1)
|
Ensembl | 1,114 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-183P4 | ZFIN Curated Data | |
| Encodes | EST | cb760 | Thisse et al., 2001 | |
| Encodes | EST | fc26g06 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:66370 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191491 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212676 (1) | 1104 nt | ||
| Genomic | GenBank:CR847543 (1) | 207382 nt | ||
| Polypeptide | UniProtKB:Q6PFJ6 (1) | 219 aa |
- Ishibashi, K., Shichino, Y., Han, P., Wakabayashi, K., Mito, M., Inada, T., Kimura, S., Iwasaki, S., Mishima, Y. (2024) Translation of zinc finger domains induces ribosome collision and Znf598-dependent mRNA decay in zebrafish. PLoS Biology. 22:e3002887e3002887
- Vöcking, O., Famulski, J.K. (2023) A temporal single cell transcriptome atlas of zebrafish anterior segment development. Scientific Reports. 13:56565656
- Niksirat, H., Siino, V., Steinbach, C., Levander, F. (2021) High-Resolution Proteomic Profiling Shows Sexual Dimorphism in Zebrafish Heart-Associated Proteins. Journal of Proteome Research. 20(8):4075-4088
- Hemalatha, D., Rangasamy, B., Nataraj, B., Maharajan, K., Narayanasamy, A., Ramesh, M. (2020) Transcriptional, biochemical and histological alterations in adult zebrafish (Danio rerio) exposed to benzotriazole ultraviolet stabilizer-328. The Science of the total environment. 739:139851
- Lin, W., Yan, Y., Ping, S., Li, P., Li, D., Hu, J., Liu, W., Wen, X., Ren, Y. (2020) Metformin-Induced Epigenetic Toxicity in Zebrafish: Experimental and Molecular Dynamics Simulation Studies. Environmental science & technology. 55(3):1672-1681
- Tierbach, A., Groh, K.J., Schoenenberger, R., Schirmer, K., Suter, M.J. (2020) Biotransformation capacity of zebrafish (Danio rerio) early life stages: Functionality of the mercapturic acid pathway. Toxicological sciences : an official journal of the Society of Toxicology. 176(2):355-365
- Laue, K., Rajshekar, S., Courtney, A.J., Lewis, Z.A., Goll, M.G. (2019) The maternal to zygotic transition regulates genome-wide heterochromatin establishment in the zebrafish embryo. Nature communications. 10:1551
- Parolini, M., Ghilardi, A., De Felice, B., Del Giacco, L. (2019) Environmental concentration of fluoxetine disturbs larvae behavior and increases the defense response at molecular level in zebrafish (Danio rerio). Environmental science and pollution research international. 26(34):34943-34952
- Saunders, L.M., Mishra, A.K., Aman, A.J., Lewis, V.M., Toomey, M.B., Packer, J.S., Qiu, X., McFaline-Figueroa, J.L., Corbo, J.C., Trapnell, C., Parichy, D.M. (2019) Thyroid hormone regulates distinct paths to maturation in pigment cell lineages. eLIFE. 8:
- Awoyemi, O.M., Kumar, N., Schmitt, C., Subbiah, S., Crago, J. (2018) Behavioral, molecular and physiological responses of embryo-larval zebrafish exposed to types I and II pyrethroids. Chemosphere. 219:526-537
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