Gene
add1
- ID
- ZDB-GENE-030909-2
- Name
- adducin 1 (alpha)
- Symbol
- add1 Nomenclature History
- Previous Names
-
- cb787 (1)
- zgc:158352
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to have actin filament binding activity; spectrin binding activity; and structural molecule activity. Predicted to be involved in several processes, including barbed-end actin filament capping; positive regulation of adherens junction organization; and positive regulation of establishment of endothelial barrier. Predicted to localize to several cellular components, including adherens junction; plasma membrane raft; and postsynaptic density. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; artery disease (multiple); familial combined hyperlipidemia; and gastroschisis. Is expressed in nervous system and pronephric duct. Orthologous to human ADD1 (adducin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb787 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| essential hypertension | Alliance | {Hypertension, essential, salt-sensitive} | 145500 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Class II aldolase/adducin N-terminal | Class II aldolase/adducin N-terminal domain superfamily |
|---|---|---|---|
|
UniProtKB:A1A5X4
|
741 | ||
|
UniProtKB:A0A8M9PTW3
|
690 | ||
|
UniProtKB:A0A8M9P3B6
|
763 | ||
|
UniProtKB:A0A8M3ATI8
|
698 | ||
|
UniProtKB:A0A8M2B847
|
783 | ||
|
UniProtKB:A0A8M9PQH2
|
732 | ||
|
UniProtKB:A0A8M2B7V9
|
729 | ||
|
UniProtKB:A0A8M9PQG8
|
848 |
Interactions and Pathways
No data available
Plasmids
No data available