Gene
fyna
- ID
- ZDB-GENE-030903-5
- Name
- FYN proto-oncogene, Src family tyrosine kinase a
- Symbol
- fyna Nomenclature History
- Previous Names
-
- fyn
- zgc:86720
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Enables protein kinase activity. Acts upstream of or within several processes, including adherens junction maintenance; gastrulation; and regulation of cytosolic calcium ion concentration. Located in cytosol and nucleus. Is expressed in central nervous system; olfactory placode; peripheral olfactory organ; and retina. Human ortholog(s) of this gene implicated in Alzheimer's disease; alcohol dependence; and schizophrenia. Orthologous to human FYN (FYN proto-oncogene, Src family tyrosine kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6897140 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-fyna | Charlton-Perkins et al., 2019 | |
| CRISPR2-fyna | Charlton-Perkins et al., 2019 | |
| MO1-fyna,fynb | N/A | (7) |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000980 | SH2 domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Fyn/Yrk, SH2 domain | Fyn/Yrk, SH3 domain | Non-receptor tyrosine kinases involved in cell signaling | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine-threonine/tyrosine-protein kinase, catalytic domain | SH2 domain | SH2 domain superfamily | SH3 domain | SH3-like domain superfamily | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6EWH2 | InterPro | 537 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available