Gene

fyna

ID

ZDB-GENE-030903-5

Name

FYN proto-oncogene, Src family tyrosine kinase a

Symbol

fyna Nomenclature History

Previous Names

fyn
zgc:86720

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Exhibits protein kinase activity. Involved in several processes, including adherens junction maintenance; gastrulation; and protein autophosphorylation. Localizes to cytosol and nucleus. Human ortholog(s) of this gene implicated in Alzheimer's disease and schizophrenia. Is expressed in central nervous system; olfactory placode; peripheral olfactory organ; and retina. Orthologous to human FYN (FYN proto-oncogene, Src family tyrosine kinase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 6 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

IMAGE:6897140 (6 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With fyna Human Ortholog

No data available

Associated With fyna Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008266	Tyrosine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR000980	SH2 domain
Domain	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain	IPR001452	SH3 domain
Domain	IPR020635	Tyrosine-protein kinase, catalytic domain
Domain	IPR035750	Fyn/Yrk, SH3 domain
Domain	IPR047924	Fyn/Yrk, SH2 domain
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR036028	SH3-like domain superfamily
Homologous_superfamily	IPR036860	SH2 domain superfamily