Gene

mmp14b

ID
ZDB-GENE-030901-2
Name
matrix metallopeptidase 14b (membrane-inserted)
Symbol
mmp14b Nomenclature History
Previous Names
  • MT-MMPbeta
  • zMT-MMP-beta (1)
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to enable metalloendopeptidase activity and zinc ion binding activity. Acts upstream of with a positive effect on lamellipodium organization; regulation of cell migration; and regulation of extracellular matrix assembly. Acts upstream of or within several processes, including gastrulation; intramembranous ossification; and skeletal system development. Predicted to be located in extracellular matrix and membrane. Is expressed in several structures, including axis; connective tissue cell; head; myoseptum; and tail bud. Human ortholog(s) of this gene implicated in Winchester syndrome; esophagus adenocarcinoma; and myocardial infarction. Orthologous to human MMP14 (matrix metallopeptidase 14).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
7 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mmp14b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Winchester syndrome Alliance ?Winchester syndrome 277950
Associated With mmp14b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR021158 Peptidase M10A, cysteine switch, zinc binding site
Conserved_site IPR018486 Hemopexin, conserved site
Domain IPR000585 Hemopexin-like domain
Domain IPR001818 Peptidase M10, metallopeptidase
Domain IPR002477 Peptidoglycan binding-like
Domain IPR006026 Peptidase, metallopeptidase
Domain IPR021805 Peptidase M10A, matrix metallopeptidase, C-terminal
Domain IPR033739 Peptidase M10A, catalytic domain
Family IPR021190 Peptidase M10A
Homologous_superfamily IPR024079 Metallopeptidase, catalytic domain superfamily
Homologous_superfamily IPR036365 PGBD-like superfamily
Homologous_superfamily IPR036375 Hemopexin-like domain superfamily
Repeat IPR018487 Hemopexin-like repeats
Domain Details Per Protein
Protein Length Hemopexin, conserved site Hemopexin-like domain Hemopexin-like domain superfamily Hemopexin-like repeats Metallopeptidase, catalytic domain superfamily Peptidase M10A Peptidase M10A, catalytic domain Peptidase M10A, cysteine switch, zinc binding site Peptidase M10A, matrix metallopeptidase, C-terminal Peptidase M10, metallopeptidase Peptidase, metallopeptidase Peptidoglycan binding-like PGBD-like superfamily
UniProtKB:B3DFR2 621
UniProtKB:B0R0I1 621
UniProtKB:Q7T2J1 621
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations