Gene
bub1bb
- ID
- ZDB-GENE-030829-51
- Name
- BUB1 mitotic checkpoint serine/threonine kinase Bb
- Symbol
- bub1bb Nomenclature History
- Previous Names
-
- sb:cb730
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to have protein kinase activity. Predicted to be involved in meiotic sister chromatid cohesion, centromeric and mitotic spindle assembly checkpoint. Predicted to localize to condensed nuclear chromosome kinetochore. Human ortholog(s) of this gene implicated in colorectal cancer and mosaic variegated aneuploidy syndrome 1. Is expressed in hindbrain; optic tectum; pectoral fin musculature; proliferative region; and retina. Orthologous to human BUB1B (BUB1 mitotic checkpoint serine/threonine kinase B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2001
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb730 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| colorectal cancer | Alliance | Colorectal cancer, somatic | 114500 |
| mosaic variegated aneuploidy syndrome 1 | Alliance | Mosaic variegated aneuploidy syndrome 1 | 257300 |
| [Premature chromatid separation trait] | 176430 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Mad3/Bub1 homology region 1 | Mitotic spindle checkpoint protein Bub1/Mad3 |
|---|---|---|---|
|
UniProtKB:E7F5T9
|
427 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available