Gene
znfl2a
- ID
- ZDB-GENE-030828-7
- Name
- zinc finger-like gene 2a
- Symbol
- znfl2a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be active in nucleoplasm. Is expressed in several structures, including hematopoietic system; margin; mesoderm; presumptive blood; and tail bud.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu370 (23 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|
| UniProtKB:F1QCE5 | InterPro | 306 |
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- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
znfl2a-201
(1)
|
Ensembl | 1,064 nt | ||
| mRNA |
znfl2a-202
(1)
|
Ensembl | 820 nt |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
- Gimenez, G., Kalev-Zylinska, M.L., Morison, I., Bohlander, S.K., Horsfield, J.A., Antony, J. (2024) Cohesin rad21 mutation dysregulates erythropoiesis and granulopoiesis output within the whole kidney marrow of adult zebrafish. American journal of physiology. Cell physiology. 328(1):C9-C19
- Yang, S., Zhang, X., Li, X., Yin, X., Teng, L., Ji, G., Li, H. (2022) Evolutionary and Expression Analysis of MOV10 and MOV10L1 Reveals Their Origin, Duplication and Divergence. International Journal of Molecular Sciences. 23(14):
- Liu, Y., Zhu, Z., Ho, I.H.T., Shi, Y., Li, J., Wang, X., Chan, M.T.V., Cheng, C.H.K. (2020) Genetic Deletion of miR-430 Disrupts Maternal-Zygotic Transition and Embryonic Body Plan. Frontiers in genetics. 11:853
- Lai, K.P., Li, J.W., Hsu, C.H., You, M.S., Chan, T.F., Tse, W.K.F., Jiang, Y.J. (2017) Comparative transcriptomic characterization of a new mib mutant allele, mibnn2002, in zebrafish.. Gene. 642:51-57
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Hsu, C.H., Lin, J.S., Lai, K.P., Li, J.W., Chan, T.F., You, M.S., Tse, W.K., Jiang, Y.J. (2015) A new mib allele with a chromosomal deletion covering foxc1a exhibits anterior somite specification defect.. Scientific Reports. 5:10673
- Lee, E., Koo, Y., Ng, A., Wei, Y., Luby-Phelps, K., Juraszek, A., Xavier, R.J., Cleaver, O., Levine, B., and Amatruda, J.F. (2014) Autophagy is essential for cardiac morphogenesis during vertebrate development. Autophagy. 10(4):572-87
- Keightley, M.C., Layton, J.E., Hayman, J.W., Heath, J.K., and Lieschke, G.J. (2011) Mediator subunit 12 is required for neutrophil development in zebrafish. PLoS One. 6(8):e23845
- Galloway, J.L., Wingert, R.A., Thisse, C., Thisse, B., and Zon, L.I. (2008) Combinatorial regulation of novel erythroid gene expression in zebrafish. Experimental hematology. 36(4):424-432
- Hogan, B.M., Pase, L., Hall, N.E., and Lieschke, G.J. (2006) Characterisation of duplicate zinc finger like 2 erythroid precursor genes in zebrafish. Development genes and evolution. 216(9):523-529
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