Gene
map3k5
- ID
- ZDB-GENE-030827-3
- Name
- mitogen-activated protein kinase kinase kinase 5
- Symbol
- map3k5 Nomenclature History
- Previous Names
-
- Ask1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable MAP kinase kinase kinase activity. Acts upstream of or within defense response to bacterium. Is expressed in cranium. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to human MAP3K5 (mitogen-activated protein kinase kinase kinase 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu797 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa17844 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32268 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa32269 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa43368 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | MAP3K, deoxyribohydrolase domain | MAP3K, HisK-N-like globin domain | MAP3K, PH domain | MAP3K, TRAFs-binding domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site | Sterile alpha motif/pointed domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:E7F2L3 | InterPro | 1364 | |||||||||
| UniProtKB:A0A8M9P2K6 | InterPro | 1356 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
map3k5-201
(1)
|
Ensembl | 4,095 nt | ||
| mRNA |
map3k5-204
(1)
|
Ensembl | 5,774 nt | ||
| ncRNA |
map3k5-002
(1)
|
Ensembl | 730 nt | ||
| ncRNA |
map3k5-003
(1)
|
Ensembl | 930 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-257G8 | ||
| Contained in | BAC | DKEY-8O19 | ZFIN Curated Data | |
| Encodes | EST | eu797 | Thisse et al., 2005 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001161750 (1) | 4095 nt | ||
| Genomic | GenBank:BX545848 (1) | 199986 nt | ||
| Polypeptide | UniProtKB:E7F2L3 (1) | 1364 aa |
- Khrystoforova, I., Shochat-Carvalho, C., Harari, R., Henke, K., Woronowicz, K., Harris, M.P., Karasik, D. (2022) Zebrafish mutants reveal unexpected role of Lrp5 in osteoclast regulation. Frontiers in endocrinology. 13:985304
- Gong, L., Zhou, H., Wang, C., He, L., Guo, C., Peng, C., Li, Y. (2021) Hepatoprotective effect of Forsythiaside A against acetaminophen-induced liver injury in zebrafish: coupling network pharmacology with biochemical pharmacology. Journal of ethnopharmacology. 271:113890
- Quan, Y., Gong, L., He, J., Zhou, Y., Liu, M., Cao, Z., Li, Y., Peng, C. (2019) Aloe emodin induces hepatotoxicity by activating NF-κB inflammatory pathway and P53 apoptosis pathway in zebrafish. Toxicology letters. 306:66-79
- Yang, D., Liu, X., Xu, W., Gu, Z., Yang, C., Zhang, L., Tan, J., Zheng, X., Wang, Z., Quan, S., Zhang, Y., Liu, Q. (2019) The Edwardsiella piscicida thioredoxin-like protein inhibits ASK1-MAPKs signaling cascades to promote pathogenesis during infection. PLoS pathogens. 15:e1007917
- Zimmerman, M.W., Liu, Y., He, S., Durbin, A.D., Abraham, B.J., Easton, J., Shao, Y., Xu, B., Zhu, S., Zhang, X., Li, Z., Weichert-Leahey, N., Young, R.A., Zhang, J., Look, A.T. (2018) MYC Drives a Subset of High-Risk Pediatric Neuroblastomas and Is Activated through Mechanisms Including Enhancer Hijacking and Focal Enhancer Amplification. Cancer discovery. 8:320-335
- Li, F., Wang, H., Liu, J., Lin, J., Zeng, A., Ai, W., Wang, X., Dahlgren, R.A., Wang, H. (2016) Immunotoxicity of β-Diketone Antibiotic Mixtures to Zebrafish (Danio rerio) by Transcriptome Analysis. PLoS One. 11:e0152530
- Pu, L., Zhang, L.C., Zhang, J.S., Song, X., Wang, L.G., Liang, J., Zhang, Y.B., Liu, X., Yan, H., Zhang, T., Yue, J.W., Li, N., Wu, Q.Q., Wang, L.X. (2016) Porcine MAP3K5 analysis: molecular cloning, characterization, tissue expression pattern, and copy number variations associated with residual feed intake. Genetics and molecular research : GMR. 15(3)
- Briolat, V., Jouneau, L., Carvalho, R., Palha, N., Langevin, C., Herbomel, P., Schwartz, O., Spaink, H.P., Levraud, J.P., Boudinot, P. (2014) Contrasted Innate Responses to Two Viruses in Zebrafish: Insights into the Ancestral Repertoire of Vertebrate IFN-Stimulated Genes. Journal of immunology (Baltimore, Md. : 1950). 192:4328-41
- Lo, J., Lee, S., Xu, M., Liu, F., Ruan, H., Eun, A., He, Y., Ma, W., Wang, W., Wen, Z., and Peng, J. (2003) 15,000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Genome research. 13(3):455-466
- Inohara, N. and Nuñez, G. (2000) Genes with homology to mammalian apoptosis regulators identified in zebrafish. Cell death and differentiation. 7(5):509-510
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