Gene
mvp
- ID
- ZDB-GENE-030826-33
- Name
- major vault protein
- Symbol
- mvp Nomenclature History
- Previous Names
-
- cb771 (1)
- wu:fb52b05
- wu:fc02g01
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Involved in brain development; eye development; and neuron projection regeneration. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in mitral valve prolapse. Is expressed in several structures, including digestive system; hatching gland; nervous system; periderm; and polster. Orthologous to human MVP (major vault protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb771 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Blaker-Lee et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR000048 | IQ motif, EF-hand binding site |
| Domain | IPR021870 | Major vault protein, shoulder domain |
| Domain | IPR040989 | Major vault protein repeat domain 3 |
| Domain | IPR041134 | Major vault protein repeat domain 2 |
| Domain | IPR041136 | Major vault protein repeat domain 4 |
| Domain | IPR041139 | Major vault protein repeat domain |
| Family | IPR039059 | Major vault protein |
| Homologous_superfamily | IPR036013 | Band 7/SPFH domain superfamily |
| Homologous_superfamily | IPR043023 | Major vault protein repeat domain superfamily |
| Homologous_superfamily | IPR043179 | Major vault protein repeat domain 2 superfamily |
| Repeat | IPR002499 | Major vault protein, N-terminal |
Domain Details Per Protein
| Protein | Length | Band 7/SPFH domain superfamily | IQ motif, EF-hand binding site | Major vault protein | Major vault protein, N-terminal | Major vault protein repeat domain | Major vault protein repeat domain 2 | Major vault protein repeat domain 2 superfamily | Major vault protein repeat domain 3 | Major vault protein repeat domain 4 | Major vault protein repeat domain superfamily | Major vault protein, shoulder domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6P3L0
|
863 | |||||||||||
|
UniProtKB:E9QEQ6
|
870 |
Interactions and Pathways
No data available
Plasmids
No data available