Gene

tpm3

ID
ZDB-GENE-030826-16
Name
tropomyosin 3
Symbol
tpm3 Nomenclature History
Previous Names
  • cb674 (1)
  • fa17b11
  • fb83b01
  • fk41e01
  • hm:zeh0298 (1)
  • wu:fa17b11 (1)
  • wu:fb83b01 (1)
  • wu:fk41e01 (1)
  • zeh0298
  • zgc:77592
Type
protein_coding_gene
Location
Chr: 19 Mapping Details/Browsers
Description
Predicted to have actin filament binding activity. Involved in skeletal myofibril assembly. Predicted to localize to actin filament. Human ortholog(s) of this gene implicated in nemaline myopathy 1. Is expressed in several structures, including adaxial cell; alar plate midbrain region; axis; brain; and musculature system. Orthologous to human TPM3 (tropomyosin 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
28 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Bonnet et al., 2017
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tpm3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital fiber-type disproportion Alliance Myopathy, congenital, with fiber-type disproportion 255310
nemaline myopathy 1 Alliance CAP myopathy 1 609284
nemaline myopathy 1 Alliance Nemaline myopathy 1, autosomal dominant or recessive 609284
Associated With tpm3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR000533 Tropomyosin
Homologous_superfamily IPR014751 DNA repair protein XRCC4-like, C-terminal
Domain Details Per Protein
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations