Gene

xiap

ID
ZDB-GENE-030825-7
Name
X-linked inhibitor of apoptosis
Symbol
xiap Nomenclature History
Previous Names
  • XIAP (1)
  • birc4 (1)
  • fb73d01
  • wu:fb73d01 (1)
  • zgc:91873 (1)
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process and ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of apoptotic process; positive regulation of canonical Wnt signaling pathway; and positive regulation of protein ubiquitination. Predicted to act upstream of or within Wnt signaling pathway and apoptotic process. Predicted to be active in cytoplasm and nucleus. Is expressed in female organism; male organism; and testis. Human ortholog(s) of this gene implicated in X-linked lymphoproliferative syndrome 2 and prostate cancer. Orthologous to several human genes including XIAP (X-linked inhibitor of apoptosis).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
la012549TgTransgenic insertionUnknownUnknownDNA
la018928TgTransgenic insertionUnknownUnknownDNA
sa2739Allele with one point mutationUnknownPremature StopENU
1 - 3 of 3
Show
Sequence Targeting Reagents
No data available
Human Disease
Associated With xiap Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
X-linked lymphoproliferative syndrome 2 Alliance Lymphoproliferative syndrome, X-linked, 2 300635
1 - 1 of 1
Associated With xiap Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001841 Zinc finger, RING-type
Family IPR050784 Inhibitor of Apoptosis
Homologous_superfamily IPR013083 Zinc finger, RING/FYVE/PHD-type
Repeat IPR001370 BIR repeat
1 - 4 of 4
Domain Details Per Protein
Protein Additional Resources Length BIR repeat Inhibitor of Apoptosis Zinc finger, RING/FYVE/PHD-type Zinc finger, RING-type
UniProtKB:A2RV08 InterPro 405
1 - 1 of 1
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 14
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA xiap-201 (1) Ensembl 2,196 nt
1 - 1 of 1
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACDKEY-18F5ZFIN Curated Data
EncodesESTfb73d01ZFIN Curated Data
EncodesESTIMAGE:7144691Thisse et al., 2004
EncodescDNAMGC:91873ZFIN Curated Data
EncodescDNAMGC:158591ZFIN Curated Data
1 - 5 of 5
Show
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanXIAPX
Amino acid sequence comparison (1)
Citations
1 - 10 of 19
Show