Gene
xiap
- ID
- ZDB-GENE-030825-7
- Name
- X-linked inhibitor of apoptosis
- Symbol
- xiap Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process and ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of apoptotic process; positive regulation of canonical Wnt signaling pathway; and positive regulation of protein ubiquitination. Predicted to act upstream of or within Wnt signaling pathway and apoptotic process. Predicted to be active in cytoplasm and nucleus. Is expressed in female organism; male organism; and testis. Human ortholog(s) of this gene implicated in X-linked lymphoproliferative syndrome 2 and prostate cancer. Orthologous to several human genes including XIAP (X-linked inhibitor of apoptosis).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
la012549Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la018928Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa2739 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
X-linked lymphoproliferative syndrome 2 | Alliance | Lymphoproliferative syndrome, X-linked, 2 | 300635 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | BIR repeat | Inhibitor of Apoptosis | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type |
---|---|---|---|---|---|---|
UniProtKB:A2RV08 | InterPro | 405 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-18F5 | ZFIN Curated Data | |
Encodes | EST | fb73d01 | ZFIN Curated Data | |
Encodes | EST | IMAGE:7144691 | Thisse et al., 2004 | |
Encodes | cDNA | MGC:91873 | ZFIN Curated Data | |
Encodes | cDNA | MGC:158591 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_194396 (1) | 2184 nt | ||
Genomic | GenBank:BX088535 (1) | 197465 nt | ||
Polypeptide | UniProtKB:A2RV08 (1) | 405 aa |
Species | Symbol | Chromosome | Accession # | Evidence |
---|---|---|---|---|
Human | XIAP | X | Amino acid sequence comparison (1) |
- Liu, Y., Lin, S., Wang, C., Li, T., Zheng, G., Sun, W., An, L., Bai, Y., Wu, F. (2024) Sex-Specific Effects of Environmental Exposure to the Antimicrobial Agents Benzalkonium Chloride and Triclosan on the Gut Microbiota and Health of Zebrafish (Danio rerio). Environmental science & technology. 58(35):15450-15462
- Crespo, D., Assis, L.H.C., Zhang, Y.T., Safian, D., Furmanek, T., Skaftnesmo, K.O., Norberg, B., Ge, W., Choi, Y.C., den Broeder, M.J., Legler, J., Bogerd, J., Schulz, R.W. (2021) Insulin-like 3 affects zebrafish spermatogenic cells directly and via Sertoli cells. Communications biology. 4:204
- Anton, K.A., Kajita, M., Narumi, R., Fujita, Y., Tada, M. (2018) Src-transformed cells hijack mitosis to extrude from the epithelium. Nature communications. 9:4695
- Pradhan, A., Olsson, P.E. (2018) Germ cell depletion in zebrafish leads to incomplete masculinization of the brain. General and comparative endocrinology. 265:15-21
- Wiedenhoft, H., Hayashi, L., Coffin, A.B. (2017) PI3K and Inhibitor of Apoptosis Proteins Modulate Gentamicin- Induced Hair Cell Death in the Zebrafish Lateral Line. Frontiers in Cellular Neuroscience. 11:326
- Hu, P., Liu, M., Liu, Y., Wang, J., Zhang, D., Niu, H., Jiang, S., Wang, J., Zhang, D., Han, B., Xu, Q., Chen, L. (2016) Transcriptome comparison reveals a genetic network regulating the lower temperature limit in fish. Scientific Reports. 6:28952
- Jung, I.H., Choi, J.H., Chung, Y.Y., Lim, G.L., Park, Y.N., Park, S.W. (2015) Predominant Activation of JAK/STAT3 Pathway by Interleukin-6 Is Implicated in Hepatocarcinogenesis. Neoplasia (New York, N.Y.). 17:586-97
- Fukui, H., Terai, K., Nakajima, H., Chiba, A., Fukuhara, S., Mochizuki, N. (2014) S1P-Yap1 Signaling Regulates Endoderm Formation Required for Cardiac Precursor Cell Migration in Zebrafish. Developmental Cell. 31:128-136
- Pradhan, A., Olsson, P.E. (2014) Juvenile Ovary to Testis Transition in Zebrafish Involves Inhibition of Ptges. Biology of reproduction. 91(2):33
- Hu, J., Sun, S., Jiang, Q., Sun, S., Wang, W., Gui, Y., and Song, H. (2013) Yes-associated protein (yap) is required for early embryonic development in zebrafish (danio rerio). International journal of biological sciences. 9(3):267-278
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