ZFIN is now using GRCz12tu for Genomic Data
Gene
casp9
- ID
- ZDB-GENE-030825-5
- Name
- caspase 9, apoptosis-related cysteine peptidase
- Symbol
- casp9 Nomenclature History
- Previous Names
-
- im:7136887
- zgc:101776
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable cysteine-type endopeptidase activity. Acts upstream of or within several processes, including positive regulation of apoptotic process; regulation of collateral sprouting in absence of injury; and renal filtration. Predicted to be active in cytosol. Is expressed in several structures, including gut; liver; male organism; muscle; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including Parkinson's disease; colorectal cancer; lung non-small cell carcinoma; pancreatic cancer; and type 2 diabetes mellitus. Orthologous to human CASP9 (caspase 9).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 45 figures from 37 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7136887 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-casp9 | (2) | |
| CRISPR2-casp9 | (2) | |
| MO1-casp9 | N/A | (4) |
| MO2-casp9 | N/A | Campbell et al., 2013 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR016129 | Peptidase family C14A, His active site |
| Active_site | IPR033139 | Peptidase family C14A, cysteine active site |
| Domain | IPR001309 | Peptidase C14, p20 domain |
| Domain | IPR001315 | CARD domain |
| Domain | IPR002138 | Peptidase C14, caspase non-catalytic subunit p10 |
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Domain Details Per Protein
| Protein | Additional Resources | Length | CARD domain | CASP9, CARD domain | Caspase-like domain superfamily | Death-like domain superfamily | Peptidase C14A, caspase catalytic domain | Peptidase C14, caspase domain | Peptidase C14, caspase non-catalytic subunit p10 | Peptidase C14 family | Peptidase C14, p20 domain | Peptidase family C14A, cysteine active site | Peptidase family C14A, His active site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1QSB1 | InterPro | 436 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-7I1 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7136887 | Thisse et al., 2004 | |
| Encodes | EST | fc30h06 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:101776 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:114035 | ZFIN Curated Data |
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| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001007404 (1) | 1733 nt | ||
| Genomic | GenBank:CR376748 (1) | 233351 nt | ||
| Polypeptide | UniProtKB:F1QSB1 (1) | 436 aa |
- Fernández, J.A.A., de Moura, T.C., Vila, S.F., Gaytán, J.A.R., López-Díaz, I., Learte-Aymamí, S., Vázquez, M.E., Mayán, M.D., Sánchez, L., Maurer-Morelli, C.V. (2025) Effects of two different peptides on pentylenetetrazole-induced seizures in larval zebrafish. PLoS One. 20:e0308581e0308581
- Jiang, P., Wang, J., Wang, X., Zou, L., Wu, D., Xu, Q., Jiang, Y., Yao, M., Hong, Q., Chi, X. (2025) Vitamin A attenuates PFOS-induced neurotoxicity and alters early proximity patterns to conspecifics in zebrafish larvae. Frontiers in behavioral neuroscience. 19:15646941564694
- Li, H.Y., Zeng, W.L., Ye, Y.W., Chen, X., Zhang, M.M., Chen, Y.S., Liu, C.T., Zhong, Z.Q., Li, J., Wang, Y. (2025) Glia maturation factor-β in hepatocytes enhances liver regeneration and mitigates steatosis and ballooning in zebrafish. American journal of physiology. Gastrointestinal and liver physiology. :
- Oyarbide, U., Bezzerri, V., Staton, M., Boni, C., Shah, A., Cipolli, M., Calo, E., Corey, S.J. (2025) Reduced EIF6 dosage attenuates TP53 activation in models of Shwachman-Diamond syndrome. The Journal of Clinical Investigation. :
- Wang, C., Zhong, Y., Zhang, Y., Jiang, Y., Wang, C., An, L., Luo, C., Yang, L., He, Z., Yang, Y., Luo, M., Mao, M., Wang, W., Liu, Q., Shi, Y., Ping, Y.F. (2025) Cd248a regulates pericyte development and viability in zebrafish. Communications biology. 8:451451
- Zhou, C., Zhao, H., Peng, L., Dong, Y., Wu, Q., Wang, X., Xu, Y., Wang, Y. (2025) Astragalus polysaccharide protects against cardiac injury in a tnnt2a mutant zebrafish model of dilated cardiomyopathy. BMC complementary medicine and therapies. 25:197197
- Cao, Y., Xu, F., Xia, Q., Liu, K., Lin, H., Zhang, S., Zhang, Y. (2024) The Peptide LLTRAGL Derived from Rapana venosa Exerts Protective Effect against Inflammatory Bowel Disease in Zebrafish Model by Regulating Multi-Pathways. Marine drugs. 22(3):
- de Calbiac, H., Renault, S., Haouy, G., Jung, V., Roger, K., Zhou, Q., Campanari, M.L., Chentout, L., Demy, D.L., Marian, A., Goudin, N., Edbauer, D., Guerrera, C., Ciura, S., Kabashi, E. (2024) Poly-GP accumulation due to C9orf72 loss of function induces motor neuron apoptosis through autophagy and mitophagy defects. Autophagy. 20:216421852164-2185
- Jiang, Z., Deng, L., Xiang, G., Xu, X., Wang, Y. (2024) A Mechanistic Study of the Osteogenic Effect of Arecoline in an Osteoporosis Model: Inhibition of Iron Overload-Induced Osteogenesis by Promoting Heme Oxygenase-1 Expression. Antioxidants (Basel, Switzerland). 13(4):
- Ruan, D.D., Zou, J., Liao, L.S., Ji, M.D., Wang, R.L., Zhang, J.H., Zhang, L., Gao, M.Z., Chen, Q., Yu, H.P., Wei, W., Li, Y.F., Li, H., Lin, F., Luo, J.W., Lin, X.F. (2024) In vitro study of ATP1A3 p.Ala275Pro mutant causing alternating hemiplegia of childhood and rapid-onset dystonia-parkinsonism. Frontiers in neuroscience. 18:14155761415576
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