Gene
stat5a
- ID
- ZDB-GENE-030820-2
- Name
- signal transducer and activator of transcription 5a
- Symbol
- stat5a Nomenclature History
- Previous Names
-
- stat5.1
- stat5b
- sb:eu615
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Exhibits DNA binding activity and DNA-binding transcription factor activity. Involved in several processes, including hemopoiesis; positive regulation of myeloid cell differentiation; and receptor signaling pathway via JAK-STAT. Predicted to localize to cytosol and nucleus. Is expressed in adaxial cell and liver. Orthologous to human STAT5A (signal transducer and activator of transcription 5A) and STAT5B (signal transducer and activator of transcription 5B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu615 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| growth hormone insensitivity syndrome with immune dysregulation 1 | Alliance | Growth hormone insensitivity with immune dysregulation 1, autosomal recessive | 245590 |
| growth hormone insensitivity syndrome with immune dysregulation 2 | Alliance | Growth hormone insensitivity with immune dysregulation 2, autosomal dominant | 618985 |
| Leukemia, acute promyelocytic, somatic | 102578 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000980 | SH2 domain |
| Domain | IPR013799 | STAT transcription factor, protein interaction |
| Domain | IPR013800 | STAT transcription factor, all-alpha domain |
| Domain | IPR013801 | STAT transcription factor, DNA-binding |
| Domain | IPR035858 | STAT5a/5b, DNA-binding domain |
| Domain | IPR046994 | STAT5a/5b, coiled-coil domain |
| Domain | IPR048988 | Signal transducer and activator of transcription, linker domain |
| Family | IPR001217 | Transcription factor STAT |
| Homologous_superfamily | IPR008967 | p53-like transcription factor, DNA-binding domain superfamily |
| Homologous_superfamily | IPR012345 | STAT transcription factor, DNA-binding, N-terminal |
| Homologous_superfamily | IPR015988 | STAT transcription factor, coiled coil |
| Homologous_superfamily | IPR036535 | STAT transcription factor, N-terminal domain superfamily |
| Homologous_superfamily | IPR036860 | SH2 domain superfamily |
Domain Details Per Protein
| Protein | Length | p53-like transcription factor, DNA-binding domain superfamily | SH2 domain | SH2 domain superfamily | Signal transducer and activator of transcription, linker domain | STAT5a/5b, coiled-coil domain | STAT5a/5b, DNA-binding domain | STAT transcription factor, all-alpha domain | STAT transcription factor, coiled coil | STAT transcription factor, DNA-binding | STAT transcription factor, DNA-binding, N-terminal | STAT transcription factor, N-terminal domain superfamily | STAT transcription factor, protein interaction | Transcription factor STAT |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q68SP3
|
785 |
| Type | Name | Annotation Method | Length (nt) | Analysis |
|---|---|---|---|---|
| mRNA |
stat5a-202
(1)
|
Havana | 880 nt |
Interactions and Pathways
Plasmids
No data available