Gene

lbr

ID

ZDB-GENE-030804-11

Name

lamin B receptor

Symbol

lbr Nomenclature History

Previous Names

sb:cb406
wu:fb75h08
wu:fc47b04
wu:fd36b07
zgc:86649

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to have oxidoreductase activity, acting on the CH-CH group of donors. Involved in cell migration involved in gastrulation. Localizes to nuclear inner membrane. Human ortholog(s) of this gene implicated in Greenberg dysplasia; Pelger-Huet anomaly; and primary biliary cirrhosis. Is expressed in several structures, including hypochord; nervous system; neural plate; optic vesicle; and tail bud. Orthologous to human LBR (lamin B receptor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

12 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

cb406 (13 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lbr Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Greenberg dysplasia	Alliance	Greenberg skeletal dysplasia	215140
Pelger-Huet anomaly	Alliance	Pelger-Huet anomaly	169400
		Rhizomelic skeletal dysplasia with or without Pelger-Huet anomaly	618019
		?Reynolds syndrome	613471

Associated With lbr Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018083	Sterol reductase, conserved site
Domain	IPR019023	Lamin-B receptor of TUDOR domain
Family	IPR001171	Sterol biosynthesis ERG24/DHCR-like