Gene
gpt2
- ID
- ZDB-GENE-030729-8
- Name
- glutamic pyruvate transaminase (alanine aminotransferase) 2
- Symbol
- gpt2 Nomenclature History
- Previous Names
-
- im:7150662
- sb:cb580
- zgc:165657
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable L-alanine:2-oxoglutarate aminotransferase activity and pyridoxal phosphate binding activity. Predicted to be involved in L-alanine catabolic process. Predicted to act upstream of or within biosynthetic process. Is expressed in several structures, including axial chorda mesoderm; axis; immature eye; musculature system; and nervous system. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with spastic paraplegia and microcephaly. Orthologous to human GPT2 (glutamic--pyruvic transaminase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb580 (12 images)
- IMAGE:7150662 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| neurodevelopmental disorder with spastic paraplegia and microcephaly | Alliance | Neurodevelopmental disorder with microcephaly and spastic paraplegia | 616281 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004839 | Aminotransferase, class I/classII, large domain |
| Family | IPR045088 | Aminotransferase ALAT1/2-like |
| Homologous_superfamily | IPR015421 | Pyridoxal phosphate-dependent transferase, major domain |
| Homologous_superfamily | IPR015422 | Pyridoxal phosphate-dependent transferase, small domain |
| Homologous_superfamily | IPR015424 | Pyridoxal phosphate-dependent transferase |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Aminotransferase ALAT1/2-like | Aminotransferase, class I/classII, large domain | Pyridoxal phosphate-dependent transferase | Pyridoxal phosphate-dependent transferase, major domain | Pyridoxal phosphate-dependent transferase, small domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1NDP9 | InterPro | 484 | |||||
| UniProtKB:A0AB32TZZ2 | InterPro | 544 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-283L9 | ZFIN Curated Data | |
| Encodes | EST | cb580 | Thisse et al., 2001 | |
| Encodes | EST | IMAGE:7150662 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:165657 | ZFIN Curated Data | |
| Has Artifact | cDNA | MGC:162174 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001098757 (1) | 1760 nt | ||
| Genomic | GenBank:CU672230 (2) | 107877 nt | ||
| Polypeptide | UniProtKB:A0AB32TZZ2 (1) | 544 aa |
- Wu, X., Chen, J., Liu, C., Wang, X., Zhou, H., Mai, K., He, G. (2022) Slc38a9 Deficiency Induces Apoptosis and Metabolic Dysregulation and Leads to Premature Death in Zebrafish. International Journal of Molecular Sciences. 23(8):
- Probst, J., Kölker, S., Okun, J.G., Kumar, A., Gursky, E., Posset, R., Hoffmann, G.F., Peravali, R., Zielonka, M. (2020) Chronic hyperammonemia causes a hypoglutamatergic and hyperGABAergic metabolic state associated with neurobehavioral abnormalities in zebrafish larvae. Experimental neurology. 331:113330
- Zhu, Q.S., Wang, J., He, S., Liang, X.F., Xie, S., Xiao, Q.Q. (2020) Early leucine programming on protein utilization and mTOR signaling by DNA methylation in zebrafish (Danio rerio). Nutrition & metabolism. 17:67
- Waldron, A., Wilcox, C., Francklyn, C., Ebert, A. (2019) Knock-Down of Histidyl-tRNA Synthetase Causes Cell Cycle Arrest and Apoptosis of Neuronal Progenitor Cells in vivo. Frontiers in cell and developmental biology. 7:67
- Zielonka, M., Probst, J., Carl, M., Hoffmann, G.F., Kölker, S., Okun, J.G. (2019) Bioenergetic dysfunction in a zebrafish model of acute hyperammonemic decompensation. Experimental neurology. 314:91-99
- Zielonka, M., Breuer, M., Okun, J.G., Carl, M., Hoffmann, G.F., Kölker, S. (2018) Pharmacologic rescue of hyperammonemia-induced toxicity in zebrafish by inhibition of ornithine aminotransferase. PLoS One. 13:e0203707
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Mirando, A.C., Fang, P., Williams, T.F., Baldor, L.C., Howe, A.K., Ebert, A.M., Wilkinson, B., Lounsbury, K.M., Guo, M., Francklyn, C.S. (2015) Aminoacyl-tRNA synthetase dependent angiogenesis revealed by a bioengineered macrolide inhibitor. Scientific Reports. 5:13160
- Steinke, D., Salzburger, W., Braasch, I., and Meyer, A. (2006) Many genes in fish have species-specific asymmetric rates of molecular evolution. BMC Genomics. 7(1):20
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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