Gene
helb
- ID
- ZDB-GENE-030729-16
- Name
- helicase (DNA) B
- Symbol
- helb Nomenclature History
- Previous Names
-
- id:ibd3187
- id:ibd5145
- sb:cb596
- si:dkey-150i15.3
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable single-stranded DNA helicase activity. Predicted to be involved in negative regulation of double-strand break repair via homologous recombination. Predicted to be located in chromosome; cytoplasm; and nucleus. Is expressed in several structures, including germ ring; intermediate cell mass of mesoderm; margin; tail bud; and ventral mesoderm. Orthologous to human HELB (DNA helicase B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb596 (12 images)
- eu2435 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la015325Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa15508 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20235 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa30607 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Coronaviruses polyprotein 1ab | P-loop containing nucleoside triphosphate hydrolase | UvrD-like helicase C-terminal domain |
|---|---|---|---|---|---|
| UniProtKB:B0UYS3 | InterPro | 1176 | |||
| UniProtKB:A0AB32TQK8 | InterPro | 973 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-150I15 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-87C9 | ZFIN Curated Data | |
| Encodes | EST | cb596 | Thisse et al., 2001 | |
| Encodes | EST | eu2435 | Thisse et al., 2005 | |
| Encodes | EST | ibd3187 | ||
| Encodes | EST | ibd5145 | Kudoh et al., 2001 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_001336741 (1) | 4191 nt | ||
| Genomic | GenBank:CR558305 (1) | 86313 nt | ||
| Polypeptide | UniProtKB:B0UYS3 (1) | 1176 aa |
- Xiong, G., Deng, Y., Li, J., Cao, Z., Liao, X., Liu, Y., Lu, H. (2019) Immunotoxicity and transcriptome analysis of zebrafish embryos in response to glufosinate-ammonium exposure. Chemosphere. 236:124423
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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