Gene
plaub
- ID
- ZDB-GENE-030619-15
- Name
- plasminogen activator, urokinase b
- Symbol
- plaub Nomenclature History
- Previous Names
-
- wu:fk07g01
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable serine-type endopeptidase activity. Acts upstream of or within plasminogen activation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including eye; gill; gonad; heart; and liver. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); Quebec platelet disorder; end stage renal disease; lung disease (multiple); and mitral valve prolapse. Orthologous to human PLAU (plasminogen activator, urokinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Park et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa11884 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Alzheimer's disease 1 | Alliance | {Alzheimer disease, late-onset, susceptibility to} | 104300 |
| Quebec platelet disorder | Alliance | Quebec platelet disorder | 601709 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR018114 | Serine proteases, trypsin family, histidine active site |
| Active_site | IPR033116 | Serine proteases, trypsin family, serine active site |
| Domain | IPR000001 | Kringle |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001254 | Serine proteases, trypsin domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | EGF-like domain | Kringle | Kringle-like fold | Kringle superfamily | Peptidase S1A, chymotrypsin family | Peptidase S1, PA clan | Peptidase S1, PA clan, chymotrypsin-like fold | Serine Proteases (Peptidase S1 Family) | Serine proteases, trypsin domain | Serine proteases, trypsin family, histidine active site | Serine proteases, trypsin family, serine active site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9Q858 | InterPro | 430 | |||||||||||
| UniProtKB:G8CXX6 | InterPro | 432 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-282L7 | ZFIN Curated Data | |
| Encodes | EST | fk07g01 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001252350 (1) | 2299 nt | ||
| Genomic | GenBank:FP102121 (2) | 101412 nt | ||
| Polypeptide | UniProtKB:G8CXX6 (1) | 432 aa |
- Comparative Orthology
- Alliance
- Chen, K., Wang, P., Chen, J., Ying, Y., Chen, Y., Gilson, E., Lu, Y., Ye, J. (2022) Loss of atm in Zebrafish as a Model of Ataxia-Telangiectasia Syndrome. Biomedicines. 10(2):
- Park, J.E., Kim, E., Lee, D.W., Park, T.K., Kim, M.S., Jang, S.Y., Ahn, J., Park, K.B., Kim, K.H., Park, H.C., Ki, C.S., Kim, D.K. (2021) Identification of de novo EP300 and PLAU variants in a patient with Rubinstein-Taybi syndrome-related arterial vasculopathy and skeletal anomaly. Scientific Reports. 11:15931
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Zhang, B., Shimada, Y., Hirota, T., Ariyoshi, M., Kuroyanagi, J., Nishimura, Y., Tanaka, T. (2016) Novel immunologic tolerance of human cancer cell xenotransplants in zebrafish. Translational research : the journal of laboratory and clinical medicine. 170:89-98.e3
- Chu, L., Li, J., Liu, Y., Hu, W., Cheng, C.H. (2014) Targeted gene disruption in zebrafish reveals noncanonical functions of Lh signaling in reproduction. Molecular endocrinology (Baltimore, Md.). 28(11):1785-95
- Bager, R., Kristensen, T.K., Jensen, J.K., Szczur, A., Christensen, A., Andersen, L.M., Johansen, J.S., Larsen, N., Baatrup, E., Huang, M., Ploug, M., and Andreasen, P.A. (2012) Urokinase-type plasminogen activator-like proteases in teleosts lack genuine receptor-binding epidermal growth factor-like domains. The Journal of biological chemistry. 287(33):27526-27536
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