Gene

mhc2bl

ID

ZDB-GENE-030616-99

Name

MHC class II beta chain-like

Symbol

mhc2bl Nomenclature History

Previous Names

mhc2d8.37b1 (1)
si:busm1-104n07.3
si:dz104n07.3

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to be involved in antigen processing and presentation and immune response. Predicted to localize to MHC class II protein complex and integral component of membrane. Human ortholog(s) of this gene implicated in asthma (multiple); hepatitis B; lung disease (multiple); and type 1 diabetes mellitus. Orthologous to human HLA-DPB1 (major histocompatibility complex, class II, DP beta 1); HLA-DQB2 (major histocompatibility complex, class II, DQ beta 2); and HLA-DRB5 (major histocompatibility complex, class II, DR beta 5).

Genome Resources

Note

novel protein similar to MHC class II beta chain

Comparative Information

Expression

All Expression Data

2 figures from Wu et al., 2018

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mhc2bl Human Ortholog

No data available

Associated With mhc2bl Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000353	MHC class II, beta chain, N-terminal
Domain	IPR003597	Immunoglobulin C1-set
Domain	IPR007110	Immunoglobulin-like domain
Homologous_superfamily	IPR011162	MHC classes I/II-like antigen recognition protein
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR014745	MHC class II, alpha/beta chain, N-terminal
Homologous_superfamily	IPR036179	Immunoglobulin-like domain superfamily

Domain Details Per Protein

Protein	Length	Immunoglobulin C1-set	Immunoglobulin-like domain	Immunoglobulin-like domain superfamily	Immunoglobulin-like fold	MHC classes I/II-like antigen recognition protein	MHC class II, alpha/beta chain, N-terminal	MHC class II, beta chain, N-terminal
UniProtKB:F1QVI4 InterPro	250

Transcripts

Genome Browsers

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	si:busm1-104n07.3-001 (1)	Havana	769 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	si:busm1-104n07.3-202 (1) Ensembl	Havana	723 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations