Gene

plcb3

ID

ZDB-GENE-030616-594

Name

phospholipase C, beta 3 (phosphatidylinositol-specific)

Symbol

plcb3 Nomenclature History

Previous Names

she
si:ch211-188c22.1
si:zc188c22.1
wu:fl04b08

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to have calmodulin binding activity and phosphatidylinositol phospholipase C activity. Involved in negative regulation of calcium ion import; negative regulation of vascular permeability; and skeletal system development. Is expressed in several structures, including epidermis; nervous system; otic vesicle; pharyngeal arch; and pronephric duct. Orthologous to human PLCB3 (phospholipase C beta 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

10 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

IMAGE:7154492 (22 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 15 figures from 6 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With plcb3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
spondylometaphyseal dysplasia with corneal dystrophy	Alliance	Spondylometaphyseal dysplasia with corneal dystrophy	618961

Associated With plcb3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR009535	Phospholipase C-beta, conserved site
Domain	IPR000008	C2 domain
Domain	IPR000909	Phosphatidylinositol-specific phospholipase C, X domain
Domain	IPR001711	Phospholipase C, phosphatidylinositol-specific, Y domain
Domain	IPR014815	Phospholipase C-beta, C-terminal domain
Domain	IPR015359	Phosphoinositide-specific phospholipase C, EF-hand-like domain
Domain	IPR037862	PLC-beta, PH domain
Family	IPR001192	Phosphoinositide phospholipase C family
Family	IPR016280	Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta
Homologous_superfamily	IPR011992	EF-hand domain pair
Homologous_superfamily	IPR017946	PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
Homologous_superfamily	IPR035892	C2 domain superfamily
Homologous_superfamily	IPR042531	Phospholipase C-beta, C-terminal domain superfamily

Domain Details Per Protein

Protein	Length	C2 domain	C2 domain superfamily	EF-hand domain pair	Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta	Phosphatidylinositol-specific phospholipase C, X domain	Phosphoinositide phospholipase C family	Phosphoinositide-specific phospholipase C, EF-hand-like domain	Phospholipase C-beta, conserved site	Phospholipase C-beta, C-terminal domain	Phospholipase C-beta, C-terminal domain superfamily	Phospholipase C, phosphatidylinositol-specific, Y domain	PLC-beta, PH domain	PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
UniProtKB:A2TJ25 InterPro	1244
UniProtKB:A0A0R4IVA6 InterPro	1245

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	plcb3-201 (1) Ensembl	Havana	7145 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	plcb3-002 (1) Ensembl	Havana	977 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations