Gene

scrib

ID
ZDB-GENE-030616-572
Name
scribble planar cell polarity protein
Symbol
scrib Nomenclature History
Previous Names
  • scrb1 (1)
  • landlocked
  • llk
  • scribble1 (1)
  • si:ch211-12p8.1 (1)
  • si:zc12p8.1
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Enables protein heterodimerization activity. Involved in several processes, including activation of GTPase activity; establishment of apical/basal cell polarity; and protein localization to postsynapse. Acts upstream of or within several processes, including establishment of mitotic spindle orientation; morphogenesis of an epithelium; and nervous system development. Located in membrane. Predicted to colocalize with cell leading edge; postsynaptic membrane; and presynaptic membrane. Is expressed in brain; neural tube; and secondary posterior lateral line primordium. Orthologous to human SCRIB (scribble planar cell polarity protein).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
20 figures from 11 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With scrib Human Ortholog
No data available
Associated With scrib Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001478 PDZ domain
Homologous_superfamily IPR032675 Leucine-rich repeat domain superfamily
Homologous_superfamily IPR036034 PDZ superfamily
Repeat IPR001611 Leucine-rich repeat
Repeat IPR003591 Leucine-rich repeat, typical subtype
Domain Details Per Protein
Protein Length Leucine-rich repeat Leucine-rich repeat domain superfamily Leucine-rich repeat, typical subtype PDZ domain PDZ superfamily
UniProtKB:A0A1L1QZM7 1757
UniProtKB:Q4H4B6 1724
UniProtKB:A0A0R4IWN6 1805
UniProtKB:A0A1D5NSU4 72
UniProtKB:A0A1L1QZF0 1808
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations