Gene

adh8b

ID
ZDB-GENE-030529-2
Name
alcohol dehydrogenase 8b
Symbol
adh8b Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Exhibits alcohol dehydrogenase (NAD+) activity and formaldehyde dehydrogenase activity. Involved in formaldehyde metabolic process and octanol metabolic process. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in alcohol use disorder; late onset Parkinson's disease; and pancreatic cancer. Is expressed in female organism; intestine; liver; ovary; and yolk syncytial layer. Orthologous to several human genes including ADH1A (alcohol dehydrogenase 1A (class I), alpha polypeptide); ADH1B (alcohol dehydrogenase 1B (class I), beta polypeptide); and ADH1C (alcohol dehydrogenase 1C (class I), gamma polypeptide).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
10 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With adh8b Human Ortholog
No data available
Associated With adh8b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR002328 Alcohol dehydrogenase, zinc-type, conserved site
Domain IPR013149 Alcohol dehydrogenase-like, C-terminal
Domain IPR013154 Alcohol dehydrogenase-like, N-terminal
Domain IPR020843 Polyketide synthase, enoylreductase domain
Homologous_superfamily IPR011032 GroES-like superfamily
Homologous_superfamily IPR036291 NAD(P)-binding domain superfamily
Domain Details Per Protein
Protein Length Alcohol dehydrogenase-like, C-terminal Alcohol dehydrogenase-like, N-terminal Alcohol dehydrogenase, zinc-type, conserved site GroES-like superfamily NAD(P)-binding domain superfamily Polyketide synthase, enoylreductase domain
UniProtKB:Q7T2J4 376
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations