Gene
gid8b
- ID
- ZDB-GENE-030515-4
- Name
- GID complex subunit 8 homolog b (S. cerevisiae)
- Symbol
- gid8b Nomenclature History
- Previous Names
-
- c20orf11
- cb482 (1)
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Involved in positive regulation of canonical Wnt signaling pathway. Acts upstream of or within determination of dorsal identity. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including endoderm; hatching gland; mesoderm; notochord; and tail bud. Orthologous to human GID8 (GID complex subunit 8 homolog).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb482 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Lu et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | CRA domain | CTLH/CRA C-terminal to LisH motif domain | CTLH, C-terminal LisH motif | LIS1 homology motif | Ubiquitination and Signaling Pathway Regulator |
---|---|---|---|---|---|---|---|
UniProtKB:E7FGY2 | InterPro | 229 | |||||
UniProtKB:A0AB13A8E1 | InterPro | 229 |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-195I16 | ZFIN Curated Data | |
Contained in | BAC | CH211-280C4 | ZFIN Curated Data | |
Encodes | EST | cb482 | Thisse et al., 2001 |
1 - 3 of 3
Show
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001386504 (1) | 1671 nt | ||
Genomic | GenBank:BX649300 (1) | 202963 nt | ||
Polypeptide | UniProtKB:A0AB13A8E1 (1) | 229 aa |
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Lu, Y., Xie, S., Zhang, W., Zhang, C., Gao, C., Sun, Q., Cai, Y., Xu, Z., Xiao, M., Xu, Y., Huang, X., Wu, X., Liu, W., Wang, F., Kang, Y., Zhou, T. (2017) Twa1/Gid8 is a β-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis. Cell Research. 27(12):1422-1440
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Kassahn, K.S., Dang, V.T., Wilkins, S.J., Perkins, A.C., and Ragan, M.A. (2009) Evolution of gene function and regulatory control after whole-genome duplication: Comparative analyses in vertebrates. Genome research. 19(8):1404-1418
1 - 5 of 5
Show