aldh2.2

ID

ZDB-GENE-030326-5

Name

aldehyde dehydrogenase 2 family member, tandem duplicate 2

Symbol

aldh2.2 Nomenclature History

Previous Names

aldh2
aldh2b
aldh2l
cb154 (1)
fb14d09
wu:fb14d09
wu:fi26c02
zgc:85659

Type

protein_coding_gene

Location

Ambiguous Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable aldehyde dehydrogenase (NAD+) activity. Acts upstream of or within regulation of cellular response to drug. Predicted to be located in mitochondrial matrix. Is expressed in several structures, including digestive system; fin; immature eye; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; artery disease (multiple); diabetes mellitus (multiple); and liver disease (multiple). Orthologous to human ALDH2 (aldehyde dehydrogenase 2 family member).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

10 figures from 5 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb154 (25 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With aldh2.2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Alcohol sensitivity, acute	610251
		{Esophageal cancer, alcohol-related, susceptibility to}
		{Hangover, susceptibility to}	610251
		{Sublingual nitroglycerin, susceptibility to poor response to}

Associated With aldh2.2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR016160	Aldehyde dehydrogenase, cysteine active site
Conserved_site	IPR029510	Aldehyde dehydrogenase, glutamic acid active site
Domain	IPR015590	Aldehyde dehydrogenase domain
Homologous_superfamily	IPR016161	Aldehyde/histidinol dehydrogenase
Homologous_superfamily	IPR016162	Aldehyde dehydrogenase, N-terminal
Homologous_superfamily	IPR016163	Aldehyde dehydrogenase, C-terminal