Gene

aldh2.2

ID
ZDB-GENE-030326-5
Name
aldehyde dehydrogenase 2 family member, tandem duplicate 2
Symbol
aldh2.2 Nomenclature History
Previous Names
  • aldh2
  • aldh2b
  • aldh2l
  • cb154 (1)
  • wu:fi26c02
  • zgc:85659
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to enable aldehyde dehydrogenase (NAD+) activity. Acts upstream of or within regulation of cellular response to drug. Predicted to be located in mitochondrion. Is expressed in several structures, including digestive system; fin; immature eye; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; artery disease (multiple); diabetes mellitus (multiple); and liver disease (multiple). Orthologous to human ALDH2 (aldehyde dehydrogenase 2 family member).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
10 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With aldh2.2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Alcohol sensitivity, acute 610251
{Esophageal cancer, alcohol-related, susceptibility to}
{Hangover, susceptibility to} 610251
{Sublingual nitroglycerin, susceptibility to poor response to}
1 - 4 of 4
Associated With aldh2.2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR016160 Aldehyde dehydrogenase, cysteine active site
Conserved_site IPR029510 Aldehyde dehydrogenase, glutamic acid active site
Domain IPR015590 Aldehyde dehydrogenase domain
Homologous_superfamily IPR016161 Aldehyde/histidinol dehydrogenase
Homologous_superfamily IPR016162 Aldehyde dehydrogenase, N-terminal
1 - 5 of 6 Show all
Domain Details Per Protein
Protein Additional Resources Length Aldehyde dehydrogenase, C-terminal Aldehyde dehydrogenase, cysteine active site Aldehyde dehydrogenase domain Aldehyde dehydrogenase, glutamic acid active site Aldehyde dehydrogenase, N-terminal Aldehyde/histidinol dehydrogenase
UniProtKB:Q6TH48 InterPro 516
1 - 1 of 1
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA aldh2.2-201 (1)
Ensembl
Ensembl 1,904 nt
ZFIN BLAST
mRNA aldh2.2-202 (1)
Ensembl
Ensembl 2,125 nt
ZFIN BLAST
1 - 2 of 2
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
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