Gene
clic4
- ID
- ZDB-GENE-030326-3
- Name
- chloride intracellular channel 4
- Symbol
- clic4 Nomenclature History
- Previous Names
-
- cb142 (1)
- wu:fb33c05
- wu:fc30h10
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable chloride channel activity. Predicted to be involved in chloride transport. Predicted to act upstream of or within monoatomic ion transmembrane transport. Predicted to be located in nucleus and plasma membrane. Predicted to be part of chloride channel complex. Predicted to be active in cytoplasm and membrane. Is expressed in several structures, including axis; central nervous system; immature eye; mesoderm; and pericardial region. Orthologous to human CLIC4 (chloride intracellular channel 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb142 (31 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la027832Tg | Transgenic insertion | Unknown | Unknown | DNA |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR053823 | CLIC, N-terminal domain |
| Family | IPR002946 | Intracellular chloride channel |
| Family | IPR040079 | Glutathione transferase family |
| Homologous_superfamily | IPR036249 | Thioredoxin-like superfamily |
| Homologous_superfamily | IPR036282 | Glutathione S-transferase, C-terminal domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | CLIC, N-terminal domain | Glutathione S-transferase, C-terminal domain superfamily | Glutathione transferase family | Intracellular chloride channel | Thioredoxin-like superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q7ZTT4 | InterPro | 252 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-27H18 | ZFIN Curated Data | |
| Contained in | BAC | CH211-135B6 | ZFIN Curated Data | |
| Encodes | EST | cb142 | Thisse et al., 2001 | |
| Encodes | EST | fb33c05 | ZFIN Curated Data | |
| Encodes | EST | fc30h10 | ZFIN Curated Data | |
| Encodes | EST | fb53a07 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:56617 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77133 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_201486 (1) | 2979 nt | ||
| Genomic | GenBank:AL772189 (1) | 183958 nt | ||
| Polypeptide | UniProtKB:Q7ZTT4 (1) | 252 aa |
- Ott, E., Hoff, S., Indorf, L., Ditengou, F.A., Müller, J., Renschler, G., Lienkamp, S.S., Kramer-Zucker, A., Bergmann, C., Epting, D. (2023) A novel role for the chloride intracellular channel protein Clic5 in ciliary function. Scientific Reports. 13:1764717647
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Lam, S.H., Ung, C.Y., Hlaing, M.M., Hu, J., Li, Z.H., Mathavan, S., and Gong, Z. (2013) Molecular insights into 4-nitrophenol-induced hepatotoxicity in zebrafish: Transcriptomic, histological and targeted gene expression analyses. Biochimica et biophysica acta. General subjects. 1830(10):4778-4789
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Baxendale, S., Chen, C.K., Tang, H., Davison, C., Hateren, L.V., Croning, M.D., Humphray, S.J., Hubbard, S.J., and Ingham, P.W. (2009) Expression screening and annotation of a zebrafish myoblast cDNA library. Gene expression patterns : GEP. 9(2):73-82
- Gabashvili, I.S., Sokolowski, B.H., Morton, C.C., and Giersch, A.B. (2007) Ion Channel Gene Expression in the Inner Ear. Journal of the Association for Research in Otolaryngology : JARO. 8(3):305-328
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Kohn, M., Hogel, J., Vogel, W., Minich, P., Kehrer-Sawatzki, H., Graves, J.A., and Hameister, H. (2006) Reconstruction of a 450-My-old ancestral vertebrate protokaryotype. Trends in genetics : TIG. 22(4):203-210
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Song, H.D., Sun, X.J., Deng, M., Zhang, G.W., Zhou, Y., Wu, X.Y., Sheng, Y., Chen, Y., Ruan, Z., Jiang, C.L., Fan, H.Y., Zon, L.I., Kanki, J.P., Liu, T.X., Look, A.T., and Chen, Z. (2004) Hematopoietic gene expression profile in zebrafish kidney marrow. Proceedings of the National Academy of Sciences of the United States of America. 101(46):16240-16245
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