Gene

dlst

ID
ZDB-GENE-030326-1
Name
dihydrolipoamide S-succinyltransferase
Symbol
dlst Nomenclature History
Previous Names
  • cb60 (1)
  • schneckentempo (1)
  • wu:fc39d01
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to have dihydrolipoyllysine-residue succinyltransferase activity. Involved in several processes, including ATP biosynthetic process; heart contraction; and mitochondrion morphogenesis. Predicted to localize to oxoglutarate dehydrogenase complex. Human ortholog(s) of this gene implicated in Alzheimer's disease and paraganglioma. Is expressed in several structures, including immature eye; musculature system; nervous system; neural plate; and segmental plate. Orthologous to human DLST (dihydrolipoamide S-succinyltransferase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dlst Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Paragangliomas 7 618475
Associated With dlst Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR003016 2-oxo acid dehydrogenase, lipoyl-binding site
Domain IPR000089 Biotin/lipoyl attachment
Domain IPR001078 2-oxoacid dehydrogenase acyltransferase, catalytic domain
Family IPR006255 Dihydrolipoamide succinyltransferase
Homologous_superfamily IPR011053 Single hybrid motif
Homologous_superfamily IPR023213 Chloramphenicol acetyltransferase-like domain superfamily
Domain Details Per Protein
Protein Length 2-oxoacid dehydrogenase acyltransferase, catalytic domain 2-oxo acid dehydrogenase, lipoyl-binding site Biotin/lipoyl attachment Chloramphenicol acetyltransferase-like domain superfamily Dihydrolipoamide succinyltransferase Single hybrid motif
UniProtKB:A0A2R8QEC5 451
UniProtKB:F1QFQ6 458
UniProtKB:Q7ZVL3 458
UniProtKB:A0A2R8QC07 436
UniProtKB:Q6NZW7 457
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations