Gene
tiam2a
- ID
- ZDB-GENE-030219-98
- Name
- TIAM Rac1 associated GEF 2a
- Symbol
- tiam2a Nomenclature History
- Previous Names
-
- id:ibd5033
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in positive regulation of axonogenesis and small GTPase-mediated signal transduction. Predicted to act upstream of or within activation of GTPase activity and intracellular signal transduction. Predicted to be located in nucleus. Predicted to be active in membrane and synapse. Is expressed in somite and tail bud. Orthologous to human TIAM2 (TIAM Rac1 associated GEF 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from Kudoh et al., 2001
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | CID domain | Dbl homology (DH) domain superfamily | Dbl homology domain | ENTH/VHS | Guanine-nucleotide dissociation stimulator, CDC24, conserved site | Nucleotide-binding alpha-beta plait domain superfamily | PDZ domain | PDZ superfamily | PH-like domain superfamily | Pleckstrin homology domain | Raf-like Ras-binding | RNA-binding domain superfamily | RNA recognition motif domain | SCAF8, RNA recognition motif | SR-related and CTD-associated factor | Tiam1/2, second PH-like domain | TIAM1, CC-Ex domain | Tiam1/Tiam2/Protein still life |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A286Y9S9 | InterPro | 1671 | ||||||||||||||||||
| UniProtKB:A0A8M3AJ94 | InterPro | 1686 | ||||||||||||||||||
| UniProtKB:A0A8M3AK43 | InterPro | 728 | ||||||||||||||||||
| UniProtKB:A0A8M9PLL7 | InterPro | 673 | ||||||||||||||||||
| UniProtKB:A0AB32T4C6 | InterPro | 1652 |
1 - 5 of 6 Show all
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tiam2a-201
(1)
|
Ensembl | 6,529 nt | ||
| mRNA |
tiam2a-202
(1)
|
Ensembl | 558 nt | ||
| mRNA |
tiam2a-203
(1)
|
Ensembl | 5,106 nt | ||
| mRNA |
tiam2a-204
(1)
|
Ensembl | 5,049 nt | ||
| mRNA |
tiam2a-205
(1)
|
Ensembl | 5,583 nt |
1 - 5 of 7 Show all
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-215H5 | ZFIN Curated Data | |
| Contained in | BAC | CH73-284N17 | ZFIN Curated Data | |
| Encodes | EST | ibd5033 | ||
| Has Artifact | EST | fc50c06 | ZFIN Curated Data |
1 - 4 of 4
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068214646 (1) | 5985 nt | ||
| Genomic | GenBank:CU694254 (1) | 88129 nt | ||
| Polypeptide | UniProtKB:A0A8M3AJ94 (1) | 1686 aa |
- Tabor, K.M., Marquart, G.D., Hurt, C., Smith, T.S., Geoca, A.K., Bhandiwad, A.A., Subedi, A., Sinclair, J.L., Rose, H.M., Polys, N.F., Burgess, H.A. (2019) Brain-wide cellular resolution imaging of Cre transgenic zebrafish lines for functional circuit-mapping. eLIFE. 8
- Tabor, K.M., Smith, T.S., Brown, M., Bergeron, S.A., Briggman, K.L., Burgess, H.A. (2018) Presynaptic Inhibition Selectively Gates Auditory Transmission to the Brainstem Startle Circuit. Current biology : CB. 28(16):2527-2535.e8
- Marquart, G.D., Tabor, K.M., Horstick, E.J., Brown, M., Geoca, A.K., Polys, N.F., Nogare, D.D., Burgess, H.A. (2017) High-precision registration between zebrafish brain atlases using symmetric diffeomorphic normalization. GigaScience. 6:1-15
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Marquart, G.D., Tabor, K.M., Brown, M., Strykowski, J.L., Varshney, G.K., LaFave, M.C., Mueller, T., Burgess, S.M., Higashijima, S., Burgess, H.A. (2015) A 3D Searchable Database of Transgenic Zebrafish Gal4 and Cre Lines for Functional Neuroanatomy Studies. Frontiers in neural circuits. 9:78
- Tabor, K.M., Bergeron, S.A., Horstick, E.J., Jordan, D.C., Aho, V., Porkka-Heiskanen, T., Haspel, G., Burgess, H.A. (2014) Direct activation of the Mauthner cell by electric field pulses drives ultra-rapid escape responses. Journal of neurophysiology. 112(4):834-44
- Dalton, L.E., Kamarashev, J., Ramirez, I.R., White, G., Malliri, A., and Hurlstone, A. (2013) Constitutive Rac Activation is not Sufficient to Initiate Melanocyte Neoplasia but Accelerates Malignant Progression. The Journal of investigative dermatology. 133(6):1572-81
- Krens, S.F., Corredor-Adamez, M., He, S., Snaar-Jagalska, B.E., and Spaink, H.P. (2008) ERK1 and ERK2 MAPK are key regulators of distinct gene sets in zebrafish embryogenesis. BMC Genomics. 9:196
1 - 8 of 8
Show