ZFIN is now using GRCz12tu for Genomic Data
Gene
tiam2a
- ID
- ZDB-GENE-030219-98
- Name
- TIAM Rac1 associated GEF 2a
- Symbol
- tiam2a Nomenclature History
- Previous Names
-
- id:ibd5033
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in positive regulation of axonogenesis and small GTPase-mediated signal transduction. Predicted to be active in membrane and synapse. Is expressed in somite and tail bud. Orthologous to human TIAM2 (TIAM Rac1 associated GEF 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from Kudoh et al., 2001
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR001331 | Guanine-nucleotide dissociation stimulator, CDC24, conserved site |
| Domain | IPR000219 | Dbl homology domain |
| Domain | IPR000504 | RNA recognition motif domain |
| Domain | IPR001478 | PDZ domain |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR003116 | Raf-like Ras-binding |
| Domain | IPR006569 | CID domain |
| Domain | IPR034370 | SCAF8, RNA recognition motif |
| Domain | IPR040655 | TIAM1, CC-Ex domain |
| Domain | IPR055230 | Tiam1/2, second PH-like domain |
| Family | IPR043537 | Tiam1/Tiam2/Protein still life |
| Family | IPR051485 | SR-related and CTD-associated factor |
| Homologous_superfamily | IPR008942 | ENTH/VHS |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR012677 | Nucleotide-binding alpha-beta plait domain superfamily |
| Homologous_superfamily | IPR035899 | Dbl homology (DH) domain superfamily |
| Homologous_superfamily | IPR035979 | RNA-binding domain superfamily |
| Homologous_superfamily | IPR036034 | PDZ superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | CID domain | Dbl homology (DH) domain superfamily | Dbl homology domain | ENTH/VHS | Guanine-nucleotide dissociation stimulator, CDC24, conserved site | Nucleotide-binding alpha-beta plait domain superfamily | PDZ domain | PDZ superfamily | PH-like domain superfamily | Pleckstrin homology domain | Raf-like Ras-binding | RNA-binding domain superfamily | RNA recognition motif domain | SCAF8, RNA recognition motif | SR-related and CTD-associated factor | Tiam1/2, second PH-like domain | TIAM1, CC-Ex domain | Tiam1/Tiam2/Protein still life |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A286Y9S9 | InterPro | 1671 | ||||||||||||||||||
| UniProtKB:A0A8M3AJ94 | InterPro | 1686 | ||||||||||||||||||
| UniProtKB:A0A8M3AK43 | InterPro | 728 | ||||||||||||||||||
| UniProtKB:A0A8M9PLL7 | InterPro | 673 | ||||||||||||||||||
| UniProtKB:A0AB32T4C6 | InterPro | 1652 | ||||||||||||||||||
| UniProtKB:A0AB32T4C8 | InterPro | 1286 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tiam2a-201
(1)
|
Ensembl | 6,529 nt | ||
| mRNA |
tiam2a-202
(1)
|
Ensembl | 558 nt | ||
| mRNA |
tiam2a-203
(1)
|
Ensembl | 5,106 nt | ||
| mRNA |
tiam2a-204
(1)
|
Ensembl | 5,049 nt | ||
| mRNA |
tiam2a-205
(1)
|
Ensembl | 5,583 nt | ||
| mRNA |
tiam2a-206
(1)
|
Ensembl | 4,843 nt | ||
| mRNA |
tiam2a-207
(1)
|
Ensembl | 4,716 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers