Gene

myh9b

ID
ZDB-GENE-030131-998
Name
myosin, heavy chain 9b, non-muscle
Symbol
myh9b Nomenclature History
Previous Names
  • myh91
  • myh9l1
  • myhz9 (1)
  • fb55d12
  • myo2hc9 (1)
  • si:ch211-150d5.2
  • wu:fb30g06
  • wu:fb55d12
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to enable actin filament binding activity and microfilament motor activity. Acts upstream of or within several processes, including actin filament bundle distribution; cardiac ventricle development; and midbrain-hindbrain boundary morphogenesis. Predicted to be located in cell cortex; cortical granule; and cytoskeleton. Predicted to be part of myosin II complex. Predicted to be active in cytoplasm and myosin filament. Is expressed in several structures, including brain; ectoderm; epidermis; eye; and pectoral fin. Human ortholog(s) of this gene implicated in several diseases, including auditory system disease (multiple); autosomal dominant Alport syndrome; blood platelet disease (multiple); end stage renal disease; and orofacial cleft. Orthologous to human MYH9 (myosin heavy chain 9).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
5 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With myh9b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 17 Alliance Deafness, autosomal dominant 17 603622
MYH-9 related disease Alliance Macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss 155100
1 - 2 of 2
Associated With myh9b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR000048 IQ motif, EF-hand binding site
Domain IPR001609 Myosin head, motor domain-like
Domain IPR002928 Myosin tail
Domain IPR004009 Myosin, N-terminal, SH3-like
Homologous_superfamily IPR008989 Myosin S1 fragment, N-terminal
1 - 5 of 7 Show all
Domain Details Per Protein
Protein Additional Resources Length IQ motif, EF-hand binding site Kinesin motor domain superfamily Myosin head, motor domain-like Myosin, N-terminal, SH3-like Myosin S1 fragment, N-terminal Myosin tail P-loop containing nucleoside triphosphate hydrolase
UniProtKB:A0A8M2BB06 InterPro 1691
UniProtKB:A0A8M1QUS6 InterPro 1698
1 - 2 of 2
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA myh9b-201 (1)
Ensembl
Ensembl 9,625 nt
ZFIN BLAST
mRNA myh9b-202 (1)
Ensembl
Ensembl 5,253 nt
ZFIN BLAST
mRNA myh9b-203 (1)
Ensembl
Ensembl 9,604 nt
ZFIN BLAST
1 - 3 of 3
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
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