ZFIN is now using GRCz12tu for Genomic Data
Gene
hells
- ID
- ZDB-GENE-030131-9923
- Name
- helicase, lymphoid specific
- Symbol
- hells Nomenclature History
- Previous Names
-
- cb65 (1)
- im:6911667
- sb:cb65
- sb:cb749
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable DNA binding activity; chromatin binding activity; and nucleosome array spacer activity. Acts upstream of or within chromosomal DNA methylation maintenance following DNA replication. Predicted to be active in chromatin and nucleus. Is expressed in several structures, including alar plate midbrain region; central nervous system; immature eye; margin; and pectoral fin musculature. Human ortholog(s) of this gene implicated in immunodeficiency-centromeric instability-facial anomalies syndrome 4. Orthologous to human HELLS (helicase, lymphoid specific).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 20 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb65 (7 images)
- cb749 (18 images)
- IMAGE:6911667 (3 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Dunican et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-hells | Buono et al., 2021 | |
| CRISPR2-hells | Buono et al., 2021 | |
| MO1-hells | N/A | Eckfeldt et al., 2005 |
| MO2-hells | N/A | Huang et al., 2013 |
| MO3-hells | N/A | Dunican et al., 2015 |
1 - 5 of 5
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency-centromeric instability-facial anomalies syndrome 4 | Alliance | Immunodeficiency-centromeric instability-facial anomalies syndrome 4 | 616911 |
1 - 1 of 1
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Helicase, C-terminal domain-like | Helicase superfamily 1/2, ATP-binding domain | HELLS, N-terminal | P-loop containing nucleoside triphosphate hydrolase | SNF2-like, N-terminal domain superfamily | SNF2, N-terminal | SNF2/RAD5-like, C-terminal helicase domain |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q3BDS6 | InterPro | 853 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-160I12 | ZFIN Curated Data | |
| Contained in | BAC | CH211-250C4 | ZFIN Curated Data | |
| Encodes | EST | cb65 | Thisse et al., 2001 | |
| Encodes | EST | cb749 | Thisse et al., 2001 | |
| Encodes | EST | IMAGE:6911667 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:198135 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:198137 | ZFIN Curated Data |
1 - 7 of 7
Show
| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001037101 (1) | 3170 nt | ||
| Genomic | GenBank:AL935288 (1) | 181644 nt | ||
| Polypeptide | UniProtKB:Q3BDS6 (1) | 853 aa |
- Blanc, M., Antczak, P., Cousin, X., Grunau, C., Scherbak, N., Rüegg, J., Keiter, S.H. (2021) The insecticide permethrin induces transgenerational behavioral changes linked to transcriptomic and epigenetic alterations in zebrafish (Danio rerio). The Science of the total environment. 779:146404
- Buono, L., Corbacho, J., Naranjo, S., Almuedo-Castillo, M., Moreno-Marmol, T., de la Cerda, B., Sanbria-Reinoso, E., Polvillo, R., Díaz-Corrales, F.J., Bogdanovic, O., Bovolenta, P., Martínez-Morales, J.R. (2021) Analysis of gene network bifurcation during optic cup morphogenesis in zebrafish. Nature communications. 12:3866
- Can, H., Chanumolu, S.K., Gonzalez-Muñoz, E., Prukudom, S., Otu, H.H., Cibelli, J.B. (2020) Comparative analysis of single-cell transcriptomics in human and Zebrafish oocytes. BMC Genomics. 21:471
- Rajshekar, S., Yao, J., Arnold, P.K., Payne, S.G., Zhang, Y., Bowman, T.V., Schmitz, R.J., Edwards, J.R., Goll, M. (2018) Pericentromeric hypomethylation elicits an interferon response in an animal model of ICF syndrome. eLIFE. 7:
- Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U. (2015) Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. The Journal of comparative neurology. 523(8):1202-21
- Dunican, D.S., Pennings, S., Meehan, R.R. (2015) Lsh Is Essential for Maintaining Global DNA Methylation Levels in Amphibia and Fish and Interacts Directly with Dnmt1. BioMed Research International. 2015:740637
- Baraban, S.C., Dinday, M.T., and Hortopan, G.A. (2013) Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. Nature communications. 4:2410
- Huang, H.T., Kathrein, K.L., Barton, A., Gitlin, Z., Huang, Y.H., Ward, T.P., Hofmann, O., Dibiase, A., Song, A., Tyekucheva, S., Hide, W., Zhou, Y., and Zon, L.I. (2013) A network of epigenetic regulators guides developmental haematopoiesis in vivo. Nature cell biology. 15(12):1516-1525
- Recher, G., Jouralet, J., Brombin, A., Heuzé, A., Mugniery, E., Hermel, J.M., Desnoulez, S., Savy, T., Herbomel, P., Bourrat, F., Peyriéras, N., Jamen, F., and Joly, J.S. (2013) Zebrafish midbrain slow-amplifying progenitors exhibit high levels of transcripts for nucleotide and ribosome biogenesis. Development (Cambridge, England). 140(24):4860-9
- Wang, L., Fu, C., Fan, H., Du, T., Dong, M., Chen, Y., Jin, Y., Zhou, Y., Deng, M., Gu, A., Jing, Q., Liu, T., and Zhou, Y. (2013) miR-34b regulates multiciliogenesis during organ formation in zebrafish. Development (Cambridge, England). 140(13):2755-2764
1 - 10 of 13
Show