ZFIN is now using GRCz12tu for Genomic Data
Gene
klhl41b
- ID
- ZDB-GENE-030131-9875
- Name
- kelch-like family member 41b
- Symbol
- klhl41b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Acts upstream of or within regulation of sarcomere organization; striated muscle cell development; and swimming behavior. Predicted to be located in membrane and sarcoplasmic reticulum. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in M band; cytoskeleton; and sarcoplasmic reticulum membrane. Is expressed in adaxial cell; musculature system; pericardial region; and somite. Human ortholog(s) of this gene implicated in nemaline myopathy 9. Orthologous to human KLHL41 (kelch like family member 41).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb52 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Gupta et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| nemaline myopathy 9 | Alliance | Nemaline myopathy 9 | 615731 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000210 | BTB/POZ domain |
| Domain | IPR011705 | BTB/Kelch-associated |
| Domain | IPR030571 | Kelch-like protein 41/41b, BTB/POZ domain |
| Family | IPR017096 | BTB-kelch protein |
| Homologous_superfamily | IPR011333 | SKP1/BTB/POZ domain superfamily |
| Homologous_superfamily | IPR015915 | Kelch-type beta propeller |
| Repeat | IPR006652 | Kelch repeat type 1 |
Domain Details Per Protein
| Protein | Additional Resources | Length | BTB/Kelch-associated | BTB-kelch protein | BTB/POZ domain | Kelch-like protein 41/41b, BTB/POZ domain | Kelch repeat type 1 | Kelch-type beta propeller | SKP1/BTB/POZ domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1QEG2 | InterPro | 605 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
klhl41b-201
(1)
|
Ensembl | 4,255 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers