Gene
ptbp1b
- ID
- ZDB-GENE-030131-9796
- Name
- polypyrimidine tract binding protein 1b
- Symbol
- ptbp1b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable mRNA binding activity. Predicted to be involved in regulation of RNA splicing and regulation of cell differentiation. Predicted to be active in nucleus. Is expressed in several structures, including EVL; axis; mesoderm; nervous system; and pronephric duct. Orthologous to human PTBP1 (polypyrimidine tract binding protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb363 (10 images)
- IMAGE:7145323 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa21870 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR000504 | RNA recognition motif domain |
Domain | IPR021790 | PTBP1-like, RNA recognition motif 2 |
Domain | IPR035000 | PTBP1, RNA recognition motif 1 |
Family | IPR006536 | HnRNP-L/PTB |
Homologous_superfamily | IPR012677 | Nucleotide-binding alpha-beta plait domain superfamily |
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Domain Details Per Protein
Protein | Additional Resources | Length | HnRNP-L/PTB | Nucleotide-binding alpha-beta plait domain superfamily | PTBP1-like, RNA recognition motif 2 | PTBP1, RNA recognition motif 1 | RNA-binding domain superfamily | RNA recognition motif domain |
---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M2B222 | InterPro | 547 | ||||||
UniProtKB:A0A8M3BDK1 | InterPro | 518 | ||||||
UniProtKB:F1QKG2 | InterPro | 564 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
aberrant processed transcript |
ptbp1b-205
(1)
|
Ensembl | 824 nt | ||
mRNA |
ptbp1b-201
(1)
|
Ensembl | 3,619 nt | ||
mRNA |
ptbp1b-202
(1)
|
Ensembl | 311 nt | ||
mRNA |
ptbp1b-203
(1)
|
Ensembl | 341 nt | ||
mRNA |
ptbp1b-206
(1)
|
Ensembl | 765 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-262I1 | ZFIN Curated Data | |
Encodes | EST | cb363 | Thisse et al., 2001 | |
Encodes | EST | fa04b05 | ZFIN Curated Data | |
Encodes | EST | fb16f08 | ||
Encodes | EST | fb95g10 | Rauch et al., 2003 | |
Encodes | EST | fc58e03 | ||
Encodes | EST | fi15a04 | ||
Encodes | EST | ibd2901 | ||
Encodes | EST | IMAGE:7145323 | Thisse et al., 2004 |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001122654 (1) | 3762 nt | ||
Genomic | GenBank:CR847939 (1) | 181988 nt | ||
Polypeptide | UniProtKB:F1QKG2 (1) | 564 aa |
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Li, Z., Zheng, W., Li, H., Li, C., Gong, Z. (2015) Synergistic Induction of Potential Warburg Effect in Zebrafish Hepatocellular Carcinoma by Co-Transgenic Expression of Myc and xmrk Oncogenes. PLoS One. 10:e0132319
- Hultqvist, G., Daza, D.O., Larhammar, D., and Kilimann, M.W. (2012) Evolution of the vertebrate paralemmin gene family: ancient origin of gene duplicates suggests distinct functions. PLoS One. 7(7):e41850
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