Gene
frem3
- ID
- ZDB-GENE-030131-9788
- Name
- Fras1 related extracellular matrix 3
- Symbol
- frem3 Nomenclature History
- Previous Names
-
- cb348 (1)
- fc44f01
- sb:cb348
- wu:fc44f01
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to be involved in anatomical structure morphogenesis. Is expressed in several structures, including endoderm; forebrain; head; median fin fold; and musculature system. Orthologous to human FREM3 (FRAS1 related extracellular matrix 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb348 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa9807 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa19528 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa39642 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| zko664a | Allele with one deletion | Unknown | Unknown | CRISPR | |
| zko664b | Allele with one deletion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-frem3 | (2) | |
| CRISPR2-frem3 | (2) | |
| MO1-frem3 | N/A | Carney et al., 2010 |
| MO2-frem3 | N/A | Carney et al., 2010 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003644 | Na-Ca exchanger/integrin-beta4 |
| Domain | IPR045658 | FRAS1-related extracellular matrix protein, N-terminal domain |
| Family | IPR051561 | FRAS1-related extracellular matrix |
| Homologous_superfamily | IPR038081 | CalX-like domain superfamily |
| Repeat | IPR039005 | CSPG repeat |
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Domain Details Per Protein
| Protein | Additional Resources | Length | CalX-like domain superfamily | CSPG repeat | FRAS1-related extracellular matrix | FRAS1-related extracellular matrix protein, N-terminal domain | Na-Ca exchanger/integrin-beta4 |
|---|---|---|---|---|---|---|---|
| UniProtKB:B6IDE8 | InterPro | 3127 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-27H10 | ZFIN Curated Data | |
| Encodes | EST | cb348 | Thisse et al., 2001 | |
| Encodes | EST | fc44f01 | ||
| Encodes | EST | wz13095 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001137659 (1) | 9384 nt | ||
| Genomic | GenBank:AL844217 (1) | 246026 nt | ||
| Polypeptide | UniProtKB:B6IDE8 (1) | 3127 aa |
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
- Carney, T.J., Feitosa, N.M., Sonntag, C., Slanchev, K., Kluger, J., Kiyozumi, D., Gebauer, J.M., Coffin Talbot, J., Kimmel, C.B., Sekiguchi, K., Wagener, R., Schwarz, H., Ingham, P.W., and Hammerschmidt, M. (2010) Genetic analysis of fin development in zebrafish identifies furin and hemicentin1 as potential novel Fraser Syndrome disease genes. PLoS Genetics. 6(4):e1000907
- Baxendale, S., Chen, C.K., Tang, H., Davison, C., Hateren, L.V., Croning, M.D., Humphray, S.J., Hubbard, S.J., and Ingham, P.W. (2009) Expression screening and annotation of a zebrafish myoblast cDNA library. Gene expression patterns : GEP. 9(2):73-82
- Gautier, P., Naranjo-Golborne, C., Taylor, M.S., Jackson, I.J., and Smyth, I. (2008) Expression of the fras1/frem gene family during zebrafish development and fin morphogenesis. Developmental Dynamics : an official publication of the American Association of Anatomists. 237(11):3295-3304
- Geisler, R., Rauch, G.J., Baier, H., van Bebber, F., Brobeta, L., Dekens, M.P., Finger, K., Fricke, C., Gates, M.A., Geiger, H., Geiger-Rudolph, S., Gilmour, D., Glaser, S., Gnugge, L., Habeck, H., Hingst, K., Holley, S., Keenan, J., Kirn, A., Knaut, H., Lashkari, D., Maderspacher, F., Martyn, U., Neuhauss, S., Neumann, C., Nicolson, T., Pelegri, F., Ray, R., Rick, J.M., Roehl, H., Roeser, T., Schauerte, H.E., Schier, A.F., Schönberger, U., Schönthaler, H.-B., Schulte-Merker, S., Seydler, C., Talbot, W.S., Weiler, C., Nüsslein-Volhard, C., and Haffter, P. (1999) A radiation hybrid map of the zebrafish genome. Nature Genetics. 23(1):86-89
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