Gene
ccne2
- ID
- ZDB-GENE-030131-9689
- Name
- cyclin E2
- Symbol
- ccne2 Nomenclature History
- Previous Names
-
- cb165 (1)
- sb:cb165
- zgc:86724
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in G1/S transition of mitotic cell cycle and positive regulation of G1/S transition of mitotic cell cycle. Predicted to act upstream of or within cell division. Predicted to be part of cyclin E1-CDK2 complex and cyclin E2-CDK2 complex. Predicted to be active in cytoplasm; microtubule organizing center; and nucleus. Is expressed in brain; digestive system; head; and proliferative region. Human ortholog(s) of this gene implicated in castration-resistant prostate carcinoma. Orthologous to human CCNE2 (cyclin E2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb165 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cyclin | Cyclin, C-terminal domain | Cyclin-like domain | Cyclin-like superfamily | Cyclin, N-terminal | Cyclins, cyclin-box |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6IQK5 | InterPro | 392 | ||||||
| UniProtKB:A0A8M9PD24 | InterPro | 392 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-233C16 | ZFIN Curated Data | |
| Contains | STS | chunp6696 | ||
| Encodes | EST | cb165 | Thisse et al., 2001 | |
| Encodes | cDNA | MGC:86724 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002075 (1) | 2163 nt | ||
| Genomic | GenBank:BX324007 (1) | 165294 nt | ||
| Polypeptide | UniProtKB:A0A8M9PD24 (1) | 392 aa |
No data available
- Guo, D., Xiong, H., Yang, Z., Zhang, R., Shi, P., Yao, Y., Liu, M., Xu, C., Wang, Q.K. (2024) Lysosomal membrane protein TMEM106B modulates hematopoietic stem and progenitor cell proliferation and differentiation by regulating LAMP2A stability. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 38:e23870e23870
- Zhu, B., Zhang, Z., Pardeshi, L., Chen, Y., Ge, W. (2024) Role of Y box-binding protein 1 (Ybx1) in zebrafish folliculogenesis: Promoting follicle cell proliferation via suppression of p21 (cdkn1a). Development (Cambridge, England). 151(21):
- Li, Y., Liu, C., Bai, X., Li, M., Duan, C. (2023) FK506-binding protein 5 regulates cell quiescence-proliferation decision in zebrafish epithelium. FEBS letters. 597(14):1868-1879
- Cao, L., Fang, H., Yan, D., Wu, X.M., Zhang, J., Chang, M.X. (2022) CD44a functions as a regulator of p53 signaling, apoptosis and autophagy in the antibacterial immune response. Communications biology. 5:889
- Kang, Q., Zheng, J., Jia, J., Xu, Y., Bai, X., Chen, X., Zhang, X.K., Wong, F.S., Zhang, C., Li, M. (2022) Disruption of the glucagon receptor increases glucagon expression beyond α-cell hyperplasia in zebrafish. The Journal of biological chemistry. 298(12):102665
- Ren, Y., Wang, C., Wang, H., Chang, Q., Guo, D., Wang, X. (2022) Identification of zebrafish PLEKHF2 presents in egg/embryos as an antibacterial protein. Fish & shellfish immunology. 127:925-932
- Weinreb, J.T., Gupta, V., Sharvit, E., Weil, R., Bowman, T.V. (2021) Ddx41 inhibition of DNA damage signaling permits erythroid progenitor expansion in zebrafish. Haematologica. 107(3):644-654
- Budine, T.E., de Sena-Tomás, C., Williams, M.L.K., Sepich, D.S., Targoff, K.L., Solnica-Kreze, L. (2020) Gon4l/Udu Regulates Cardiomyocyte Proliferation and Maintenance of Ventricular Chamber Identity During Zebrafish Development. Developmental Biology. 462(2):223-234
- Kuil, L.E., Oosterhof, N., Ferrero, G., Mikulášová, T., Hason, M., Dekker, J., Rovira, M., van der Linde, H.C., van Strien, P.M., de Pater, E., Schaaf, G., Bindels, E.M., Wittamer, V., van Ham, T.J. (2020) Zebrafish macrophage developmental arrest underlies depletion of microglia and reveals Csf1r-independent metaphocytes. eLIFE. 9:
- Luo, J., Liu, P., Lu, C., Bian, W., Su, D., Zhu, C., Xie, S., Pan, Y., Li, N., Cui, W., Pei, D.S., Yang, X. (2020) Stepwise crosstalk between aberrant Nf1, Tp53 and Rb signalling pathways induces gliomagenesis in zebrafish. Brain : a journal of neurology. 144(2):615-635
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