ZFIN is now using GRCz12tu for Genomic Data
Gene
lztfl1
- ID
- ZDB-GENE-030131-945
- Name
- leucine zipper transcription factor-like 1
- Symbol
- lztfl1 Nomenclature History
- Previous Names
-
- fb53f12
- wu:fb53f12
- zgc:56268
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Acts upstream of or within negative regulation of smoothened signaling pathway. Located in cytoplasm and nucleus. Is expressed in several structures, including gill; integument; liver; muscle; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 17. Orthologous to human LZTFL1 (leucine zipper transcription factor like 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7142697 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Busch-Nentwich et al., 2010
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hu2127 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| la014497Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la022841Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa9216 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| tpl55Gt | Transgenic insertion | Unknown | Unknown | DNA |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Bardet-Biedl syndrome 17 | Alliance | Bardet-Biedl syndrome 17 | 615994 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR026157 | Leucine zipper transcription factor-like protein 1 |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Leucine zipper transcription factor-like protein 1 |
|---|---|---|---|
| UniProtKB:Q7ZV21 | InterPro | 298 | |
| UniProtKB:A0A8M2BHX5 | InterPro | 228 | |
| UniProtKB:A0AB32TDP0 | InterPro | 272 | |
| UniProtKB:A0AB32TIH7 | InterPro | 239 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
lztfl1-202
(1)
|
Ensembl | 1,045 nt | ||
| mRNA |
lztfl1-203
(1)
|
Ensembl | 960 nt | ||
| mRNA |
lztfl1-205
(1)
|
Ensembl | 1,822 nt | ||
| ncRNA |
lztfl1-002
(1)
|
Ensembl | 562 nt | ||
| ncRNA |
lztfl1-003
(1)
|
Ensembl | 651 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-280A10 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-149I7 | ZFIN Curated Data | |
| Contains | SNP | rs3729466 | ZFIN Curated Data | |
| Contains | SNP | rs3729467 | ZFIN Curated Data | |
| Encodes | EST | fb53f12 | ||
| Encodes | EST | IMAGE:7142697 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:56268 | ZFIN Curated Data |
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| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199587 (1) | 1793 nt | ||
| Genomic | GenBank:CR855257 (2) | 177865 nt | ||
| Polypeptide | UniProtKB:Q7ZV21 (1) | 298 aa |
- Wei, Q., Chen, Y., Gu, Y.F., Zhao, W. (2019) Molecular Characterization and Functional Analysis of Leucine Zipper Transcription Factor Like 1 in Zebrafish (Danio rerio). Frontiers in Physiology. 10:801
- Grajevskaja, V., Camerota, D., Bellipanni, G., Balciuniene, J., Balciunas, D. (2018) Analysis of a conditional gene trap reveals that tbx5a is required for heart regeneration in zebrafish. PLoS One. 13:e0197293
- Shim, H., Kim, J.H., Kim, C.Y., Hwang, S., Kim, H., Yang, S., Lee, J.E., Lee, I. (2016) Function-driven discovery of disease genes in zebrafish using an integrated genomics big data resource. Nucleic acids research. 44:9611-9623
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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