ZFIN is now using GRCz12tu for Genomic Data

Gene

lztfl1

ID

ZDB-GENE-030131-945

Name

leucine zipper transcription factor-like 1

Symbol

lztfl1 Nomenclature History

Previous Names

fb53f12
wu:fb53f12
zgc:56268

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Acts upstream of or within negative regulation of smoothened signaling pathway. Located in cytoplasm and nucleus. Is expressed in several structures, including gill; integument; liver; muscle; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 17. Orthologous to human LZTFL1 (leucine zipper transcription factor like 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7142697 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Busch-Nentwich et al., 2010
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lztfl1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Bardet-Biedl syndrome 17	Alliance	Bardet-Biedl syndrome 17	615994

Associated With lztfl1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR026157	Leucine zipper transcription factor-like protein 1

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:Q7ZV21	InterPro	298
UniProtKB:A0A8M2BHX5	InterPro	228
UniProtKB:A0AB32TDP0	InterPro	272
UniProtKB:A0AB32TIH7	InterPro	239

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	lztfl1-202 (1) Ensembl	Ensembl	1,045 nt	Select Tool ZFIN BLAST
mRNA	lztfl1-203 (1) Ensembl	Ensembl	960 nt	Select Tool ZFIN BLAST
mRNA	lztfl1-205 (1) Ensembl	Ensembl	1,822 nt	Select Tool ZFIN BLAST
ncRNA	lztfl1-002 (1) Ensembl	Ensembl	562 nt	Select Tool ZFIN BLAST
ncRNA	lztfl1-003 (1) Ensembl	Ensembl	651 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Genome Browsers

NCBI

ZFIN

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations