Gene
ajuba
- ID
- ZDB-GENE-030131-9341
- Name
- ajuba LIM protein
- Symbol
- ajuba Nomenclature History
- Previous Names
-
- jub
- fj66b05
- wu:fj66b05
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable transcription corepressor activity. Acts upstream of or within heart development. Predicted to be part of transcription regulator complex. Predicted to be active in P-body; adherens junction; and nucleus. Is expressed in head. Orthologous to human AJUBA (ajuba LIM protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Witzel et al., 2012
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa31568 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-ajuba | (2) | |
| CRISPR2-ajuba | (2) | |
| CRISPR3-ajuba | (2) | |
| CRISPR4-ajuba | (2) | |
| CRISPR5-ajuba | (2) | |
| CRISPR6-ajuba | (2) | |
| CRISPR7-ajuba | (2) | |
| CRISPR8-ajuba | (2) | |
| CRISPR9-ajuba | (2) | |
| MO1-ajuba | N/A | (2) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Ajuba-like | Ajuba-like, LIM domain 1 | Ajuba-like, LIM domain 2 | Ajuba-like, LIM domain 3 | Zinc finger, LIM-type |
|---|---|---|---|---|---|---|---|
| UniProtKB:E7FFI0 | InterPro | 688 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-92E9 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-145J6 | ZFIN Curated Data | |
| Encodes | EST | fj66b05 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_696274 (1) | 3710 nt | ||
| Genomic | GenBank:CR936517 (1) | 60910 nt | ||
| Polypeptide | UniProtKB:E7FFI0 (1) | 688 aa |
- Szenker-Ravi, E., Ott, T., Khatoo, M., de Bellaing, A.M., Goh, W.X., Chong, Y.L., Beckers, A., Kannesan, D., Louvel, G., Anujan, P., Ravi, V., Bonnard, C., Moutton, S., Schoen, P., Fradin, M., Colin, E., Megarbane, A., Daou, L., Chehab, G., Di Filippo, S., Rooryck, C., Deleuze, J.F., Boland, A., Arribard, N., Eker, R., Tohari, S., Ng, A.Y., Rio, M., Lim, C.T., Eisenhaber, B., Eisenhaber, F., Venkatesh, B., Amiel, J., Crollius, H.R., Gordon, C.T., Gossler, A., Roy, S., Attie-Bitach, T., Blum, M., Bouvagnet, P., Reversade, B. (2021) Discovery of a genetic module essential for assigning left-right asymmetry in humans and ancestral vertebrates. Nature Genetics. 54(1):62-72
- Fukui, H., Miyazaki, T., Chow, R.W., Ishikawa, H., Nakajima, H., Vermot, J., Mochizuki, N. (2018) Hippo signaling determines the number of venous pole cells that originate from the anterior lateral plate mesoderm in zebrafish. eLIFE. 7
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Moreno-Mateos, M.A., Vejnar, C.E., Beaudoin, J.D., Fernandez, J.P., Mis, E.K., Khokha, M.K., Giraldez, A.J. (2015) CRISPRscan: designing highly efficient sgRNAs for CRISPR-Cas9 targeting in vivo. Nature Methods. 12:982-8
- Witzel, H.R., Jungblut, B., Choe, C.P., Crump, J.G., Braun, T., and Dobreva, G. (2012) The LIM Protein Ajuba Restricts the Second Heart Field Progenitor Pool by Regulating Isl1 Activity. Developmental Cell. 23(1):58-70
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