Gene

rars1

ID

ZDB-GENE-030131-9014

Name

arginyl-tRNA synthetase 1

Symbol

rars1 Nomenclature History

Previous Names

rars
wu:fa96g09
zgc:86730

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to have arginine-tRNA ligase activity. Predicted to be involved in arginyl-tRNA aminoacylation. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 9. Is expressed in digestive system; immature eye; myotome; nervous system; and somite. Orthologous to human RARS1 (arginyl-tRNA synthetase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

11 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:56050 (9 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rars1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
hypomyelinating leukodystrophy 9	Alliance	Leukodystrophy, hypomyelinating, 9	616140

Associated With rars1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR001412	Aminoacyl-tRNA synthetase, class I, conserved site
Domain	IPR005148	Arginyl tRNA synthetase N-terminal domain
Domain	IPR008909	DALR anticodon binding
Domain	IPR035684	Arginyl-tRNA synthetase, catalytic core domain
Family	IPR001278	Arginine-tRNA ligase
Homologous_superfamily	IPR009080	Aminoacyl-tRNA synthetase, class Ia, anticodon-binding
Homologous_superfamily	IPR014729	Rossmann-like alpha/beta/alpha sandwich fold
Homologous_superfamily	IPR036695	Arginyl tRNA synthetase N-terminal domain superfamily

Domain Details Per Protein

Protein	Length	Aminoacyl-tRNA synthetase, class Ia, anticodon-binding	Aminoacyl-tRNA synthetase, class I, conserved site	Arginine-tRNA ligase	Arginyl-tRNA synthetase, catalytic core domain	Arginyl tRNA synthetase N-terminal domain	Arginyl tRNA synthetase N-terminal domain superfamily	DALR anticodon binding	Rossmann-like alpha/beta/alpha sandwich fold
UniProtKB:Q7ZVF4 InterPro	661
UniProtKB:A0A8M6Z3L7 InterPro	595

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	rars-201 (1) Ensembl	Havana	2226 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	rars-202 (1) Ensembl	Havana	818 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	rars-203 (1) Ensembl	Havana	688 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	rars-204 (1) Ensembl	Havana	782 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	rars-004 (1) Ensembl	Havana	807 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations