Gene
trim69
- ID
- ZDB-GENE-030131-857
- Name
- tripartite motif containing 69
- Symbol
- trim69 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within brain development and regulation of apoptotic process. Predicted to be active in cytoplasm. Is expressed in central nervous system; fin bud; head; heart; and pleuroperitoneal region. Orthologous to several human genes including TRIM69 (tripartite motif containing 69).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | B30.2/SPRY domain | B30.2/SPRY domain superfamily | B-box-type zinc finger | Butyrophylin-like, SPRY domain | Concanavalin A-like lectin/glucanase domain superfamily | SPRY-associated | SPRY domain | Tripartite motif-containing | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type | Zinc finger, RING-type, conserved site | Zinc finger, RING-type, eukaryotic |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A060IVL7 | InterPro | 548 | ||||||||||||
| UniProtKB:A0A8M3B6K0 | InterPro | 549 | ||||||||||||
| UniProtKB:E7F8P0 | InterPro | 548 |
1 - 3 of 3
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
trim69-201
(1)
|
Ensembl | 1,651 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
- Huang, L., Zhang, L., Huo, H.J., Hou, J., Niu, M.M., Nie, P., Chen, S.N. (2023) FTR33, a member of fish-specific TRIM (finTRIM) subfamily, regulates negatively type I IFN antiviral immunity in zebrafish. Developmental and comparative immunology. 142:104671104671
- Langevin, C., Aleksejeva, E., Houel, A., Briolat, V., Torhy, C., Lunazzi, A., Levraud, J.P., Boudinot, P. (2017) FTR83, a Member of the Large Fish-Specific finTRIM Family, Triggers IFN Pathway and Counters Viral Infection. Frontiers in immunology. 8:617
- Han, R., Wang, R., Zhao, Q., Han, Y., Zong, S., Miao, S., Song, W., Wang, L. (2016) Trim69 regulates zebrafish brain development by ap-1 pathway. Scientific Reports. 6:24034
- Han, R., Zhao, Q., Zong, S., Miao, S., Song, W., Wang, L. (2016) A novel TRIM family member, trim69, regulates zebrafish development through p53-mediated apoptosis. Molecular reproduction and development. 83(5):442-54
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Boudinot, P., van der Aa, L.M., Jouneau, L., Du Pasquier, L., Pontarotti, P., Briolat, V., Benmansour, A., and Levraud, J.P. (2011) Origin and Evolution of TRIM Proteins: New Insights from the Complete TRIM Repertoire of Zebrafish and Pufferfish. PLoS One. 6(7):e22022
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
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