ZFIN is now using GRCz12tu for Genomic Data

Gene

sez6a

ID

ZDB-GENE-030131-8208

Name

seizure related 6 homolog a

Symbol

sez6a Nomenclature History

Previous Names

fj60a11
wu:fj60a11

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to be involved in regulation of dendrite development and synapse maturation. Predicted to be active in dendrite; endoplasmic reticulum; and neuronal cell body. Orthologous to human SEZ6 (seizure related 6 homolog).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa12475	Allele with one point mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
uab377	Allele with one insertion	Unknown	Unknown	CRISPR	Zebrafish International Resource Center (ZIRC) (order this)

1 - 2 of 2

Show

Sequence Targeting Reagents

No data available

Human Disease

Associated With sez6a Human Ortholog

No data available

Associated With sez6a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000436	Sushi/SCR/CCP domain
Domain	IPR000859	CUB domain
Family	IPR051277	SEZ6/CSMD/C4BPB Neuronal & Immune Regulators
Homologous_superfamily	IPR035914	Spermadhesin, CUB domain superfamily
Homologous_superfamily	IPR035976	Sushi/SCR/CCP superfamily

1 - 5 of 5

Domain Details Per Protein

Protein	Additional Resources	Length	CUB domain	SEZ6/CSMD/C4BPB Neuronal & Immune Regulators	Spermadhesin, CUB domain superfamily	Sushi/SCR/CCP domain	Sushi/SCR/CCP superfamily
UniProtKB:A0A0R4IJM1	InterPro	970
UniProtKB:A0A8M1QL49	InterPro	981

1 - 2 of 2

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Genome Assembly: GRCz11Chromosome: 10

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	sez6a-201 (1) Ensembl	Ensembl		3,697 nt	Select Tool ZFIN BLAST

1 - 1 of 1

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	CH211-128J1	CU633611	ZFIN Curated Data
Contained in	BAC	CH211-183B15	CU694807	ZFIN Curated Data
Contained in	BAC	DKEY-106A24	BX323076	ZFIN Curated Data
Encodes	EST	fj60a11	AW281979 AW305528

1 - 4 of 4

Show

Sequences

Genome Browsers

NCBI

ZFIN

Genome Assembly: GRCz12tuChromosome: 10

Type	Accession #	Genome Assembly	Length (nt/aa)	Analysis
RNA	RefSeq:XM_005169184 (1)	GRCz12tu	3510 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX323076 (1)		156437 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A0A8M1QL49 (1)		981 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Species	Symbol	Chromosome	Accession #	Evidence
Human	SEZ6	17	Ensembl:ENSG00000063015 Gene:124925 HGNC:15955 OMIM:616666	Conserved genome location (synteny) (1) Amino acid sequence comparison (1)
Mouse	Sez6	11	Ensembl:ENSMUSG00000000632 Gene:20370 MGI:104745	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)

Citations

Include unpublished citations

Zuccarini, G., D'Atri, I., Cottone, E., Mackie, K., Shainer, I., Gothilf, Y., Provero, P., Bovolin, P., Merlo, G.R. (2019) Interference with the Cannabinoid Receptor CB1R Results in Miswiring of GnRH3 and AgRP1 Axons in Zebrafish Embryos. International Journal of Molecular Sciences. 21(1):

1 - 1 of 1

Show