Gene

grm2a

ID
ZDB-GENE-030131-8097
Name
glutamate receptor, metabotropic 2a
Symbol
grm2a Nomenclature History
Previous Names
  • mglur2a (1)
  • wu:fj52c07
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to enable group II metabotropic glutamate receptor activity. Predicted to be involved in G protein-coupled glutamate receptor signaling pathway and regulation of glutamatergic synaptic transmission. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in dendrite; membrane; and synapse. Predicted to be active in plasma membrane. Is expressed in brain; retinal neural layer; and trigeminal ganglion. Orthologous to human GRM2 (glutamate metabotropic receptor 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Haug et al., 2013
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa6072Allele with one point mutationUnknownPremature StopENU
sa10180Allele with one point mutationUnknownPremature StopENU
sa20787Allele with one point mutationUnknownPremature StopENU
sa33936Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
No data available
Human Disease
Associated With grm2a Human Ortholog
No data available
Associated With grm2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017979 GPCR, family 3, conserved site
Domain IPR001828 Receptor, ligand binding region
Domain IPR011500 GPCR, family 3, nine cysteines domain
Domain IPR017978 GPCR family 3, C-terminal
Family IPR000162 GPCR, family 3, metabotropic glutamate receptor
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Domain Details Per Protein
Protein Additional Resources Length GPCR, family 3 GPCR, family 3, conserved site GPCR family 3, C-terminal GPCR, family 3, metabotropic glutamate receptor GPCR, family 3, metabotropic glutamate receptor 2 GPCR, family 3, nine cysteines domain GPCR, family 3, nine cysteines domain superfamily Metabotropic Glutamate Receptor Periplasmic binding protein-like I Receptor, ligand binding region
UniProtKB:A0A8M2BDP3 InterPro 894
UniProtKB:U3N5X6 InterPro 887
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 6
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA grm2a-201 (1) Ensembl 3,358 nt
mRNA grm2a-202 (1) Ensembl 2,560 nt
mRNA grm2a-203 (1) Ensembl 2,691 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACDKEYP-111E5ZFIN Curated Data
EncodesESTfj52c07
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanGRM23
Amino acid sequence comparison (2)
MouseGrm29
Amino acid sequence comparison (1)
Citations
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