Gene
ndst1b
- ID
- ZDB-GENE-030131-8022
- Name
- N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1b
- Symbol
- ndst1b Nomenclature History
- Previous Names
-
- ndst1
- fj47c03
- wu:fj47c03
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Enables heparan sulfate N-sulfotransferase activity. Acts upstream of or within sulfation and vasculogenesis. Predicted to be active in Golgi apparatus. Is expressed in several structures, including hindbrain; intermediate cell mass of mesoderm; myotome; pectoral fin; and somite. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 46. Orthologous to human NDST1 (N-deacetylase and N-sulfotransferase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from Filipek-Górniok et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Harfouche et al., 2009
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive intellectual developmental disorder 46 | Alliance | Intellectual developmental disorder, autosomal recessive 46 | 616116 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Heparan sulfate sulfotransferase | Heparan sulphate-N-deacetylase, deacetylase domain | P-loop containing nucleoside triphosphate hydrolase | Sulfotransferase domain |
|---|---|---|---|---|---|---|
| UniProtKB:A0A0R4IR84 | InterPro | 886 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ndst1b-201
(1)
|
Ensembl | 5,805 nt | ||
| mRNA |
ndst1b-202
(1)
|
Ensembl | 5,926 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-42P12 | ||
| Encodes | EST | fj47c03 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001324455 (1) | 5926 nt | ||
| Genomic | GenBank:BX072577 (1) | 160341 nt | ||
| Polypeptide | UniProtKB:A0A0R4IR84 (1) | 886 aa |
- Anderson, R.A., Oyarbide, U. (2022) Neuronal expression of ndst3 in early zebrafish development is responsive to Wnt signaling manipulation. Gene expression patterns : GEP. 47:119300
- Shochat, C., Wang, Z., Mo, C., Nelson, S., Donaka, R., Huang, J., Karasik, D., Brotto, M. (2020) Deletion of SREBF1, a functional bone-muscle pleiotropic gene, alters bone density and lipid signaling in zebrafish. Endocrinology. 162(1):
- Fouchécourt, S., Picolo, F., Elis, S., Lécureuil, C., Thélie, A., Govoroun, M., Brégeon, M., Papillier, P., Lareyre, J.J., Monget, P. (2019) An evolutionary approach to recover genes predominantly expressed in the testes of the zebrafish, chicken and mouse. BMC Evolutionary Biology. 19:137
- Filipek-Górniok, B., Carlsson, P., Haitina, T., Habicher, J., Ledin, J., Kjellén, L. (2015) The Ndst Gene Family in Zebrafish: Role of Ndst1b in Pharyngeal Arch Formation. PLoS One. 10:e0119040
- Desvignes, T., Contreras, A., Postlethwait, J.H. (2014) Evolution of the miR199-214 cluster and vertebrate skeletal development. RNA Biology. 11(4):281-94
- Harfouche, R., Hentschel, D.M., Piecewicz, S., Basu, S., Print, C., Eavarone, D., Kiziltepe, T., Sasisekharan, R., and Sengupta, S. (2009) Glycome and Transcriptome Regulation of Vasculogenesis. Circulation. 120(19):1883-1892
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