osgep

ID

ZDB-GENE-030131-7880

Name

O-sialoglycoprotein endopeptidase

Symbol

osgep Nomenclature History

Previous Names

fj38e02
si:ch211-214j24.11 (1)
wu:fj38e02
zgc:112527

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable N(6)-L-threonylcarbamoyladenine synthase activity and metal ion binding activity. Predicted to be involved in tRNA threonylcarbamoyladenosine modification. Predicted to act upstream of or within tRNA processing. Predicted to be located in nucleus. Predicted to be part of EKC/KEOPS complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome 3. Orthologous to human OSGEP (O-sialoglycoprotein endopeptidase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:112527 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With osgep Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Galloway-Mowat syndrome 3	Alliance	Galloway-Mowat syndrome 3	617729

Associated With osgep Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017860	Peptidase M22, conserved site
Domain	IPR000905	Gcp-like domain
Family	IPR017861	Kae1/TsaD family
Family	IPR034680	tRNA N6-adenosine threonylcarbamoyltransferase Kae1, archaeal/eukaryotic
Homologous_superfamily	IPR043129	ATPase, nucleotide binding domain