Gene

zgc:65894

ID

ZDB-GENE-030131-7741

Name

zgc:65894

Symbol

zgc:65894 Nomenclature History

Previous Names

fj33a08
wu:fj33a08

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm and microtubule. Is expressed in central nervous system; cranial ganglion; retina; retinal ganglion cell layer; and trigeminal placode. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 6 and torsion dystonia 4. Orthologous to human TUBB4A (tubulin beta 4A class IVa).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:65894 (8 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With zgc:65894 Human Ortholog

No data available

Associated With zgc:65894 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR013838	Beta tubulin, autoregulation binding site
Conserved_site	IPR017975	Tubulin, conserved site
Domain	IPR003008	Tubulin/FtsZ, GTPase domain
Domain	IPR018316	Tubulin/FtsZ, 2-layer sandwich domain
Family	IPR000217	Tubulin
Family	IPR002453	Beta tubulin
Homologous_superfamily	IPR008280	Tubulin/FtsZ, C-terminal
Homologous_superfamily	IPR023123	Tubulin, C-terminal
Homologous_superfamily	IPR036525	Tubulin/FtsZ, GTPase domain superfamily
Homologous_superfamily	IPR037103	Tubulin/FtsZ-like, C-terminal domain