Gene
elovl4b
- ID
- ZDB-GENE-030131-7672
- Name
- ELOVL fatty acid elongase 4b
- Symbol
- elovl4b Nomenclature History
- Previous Names
-
- elovl4
- wu:fk62b04
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable fatty acid elongase activity. Acts upstream of or within very long-chain fatty acid biosynthetic process. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including optic vesicle; pleuroperitoneal region; presumptive neural retina; solid lens vesicle; and visual system. Human ortholog(s) of this gene implicated in corneal dystrophy and spinocerebellar ataxia type 34. Orthologous to human ELOVL4 (ELOVL fatty acid elongase 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:73054 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- 6 figures from Nwagbo et al., 2024
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-elovl4b | (2) | |
| CRISPR2-elovl4b | Zebrafish Nomenclature Committee | |
| CRISPR3-elovl4b | Nwagbo et al., 2024 | |
| CRISPR4-elovl4b | Nwagbo et al., 2024 |
1 - 4 of 4
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| spinocerebellar ataxia type 34 | Alliance | Spinocerebellar ataxia 34 | 133190 |
| Stargardt disease | Alliance | Stargardt disease 3 | 600110 |
| Ichthyosis, spastic quadriplegia, and impaired intellectual development | 614457 |
1 - 3 of 3
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | ELO family | ELO family, conserved site | Elongation of very long chain fatty acids protein 4 |
|---|---|---|---|---|---|
| UniProtKB:Q6P978 | InterPro | 303 |
1 - 1 of 1
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
elovl4b-201
(1)
|
Ensembl | 2,533 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-100J22 | ZFIN Curated Data | |
| Encodes | EST | fk62b04 | ||
| Encodes | cDNA | MGC:73054 | ZFIN Curated Data |
1 - 3 of 3
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199972 (1) | 2436 nt | ||
| Genomic | GenBank:CR354556 (1) | 133212 nt | ||
| Polypeptide | UniProtKB:Q6P978 (1) | 303 aa |
- Nwagbo, U., Parvez, S., Maschek, J.A., Bernstein, P.S. (2024) Elovl4b Knockout Zebrafish as a Model for Ocular Very-Long-Chain Polyunsaturated Fatty Acid Deficiency. Journal of Lipid Research. 65(3):100518
- Sun, S.X., Liu, Y.C., Limbu, S.M., Li, D.L., Chen, L.Q., Zhang, M.L., Yin, Z., Du, Z.Y. (2023) Vitellogenin 1 is essential for fish reproduction by transporting DHA-containing phosphatidylcholine from liver to ovary. Biochimica et biophysica acta. Molecular and cell biology of lipids. 1868(4):159289
- Jin, M., Zhang, H., Xu, B., Li, Y., Qin, H., Yu, S., He, J. (2022) Jag2b-Notch3/1b-mediated neuron-to-glia crosstalk controls retinal gliogenesis. EMBO reports. 23(10):e54922
- Li, C., Wu, Y., Li, H., Wang, H., Liu, J.X. (2022) Lipid-related metabolism during zebrafish embryogenesis under unbalanced copper homeostasis. Fish physiology and biochemistry. 48(6):1571-1586
- Yang, G., Sun, S., He, J., Wang, Y., Ren, T., He, H., Gao, J. (2022) Enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase (ehhadh) is essential for production of DHA in zebrafish. Journal of Lipid Research. 64(3):100326
- Sun, S., Wang, Y., Goh, P.T., Lopes-Marques, M., Castro, L.F.C., Monroig, Ó., Kuah, M.K., Cao, X., Shu-Chien, A.C., Gao, J. (2021) Evolution and Functional Characteristics of the Novel elovl8 That Play Pivotal Roles in Fatty Acid Biosynthesis. Genes. 12(8):
- Takashima, S., Takemoto, S., Toyoshi, K., Ohba, A., Shimozawa, N. (2021) Zebrafish model of human Zellweger syndrome reveals organ-specific accumulation of distinct fatty acid species and widespread gene expression changes. Molecular genetics and metabolism. 133(3):307-323
- Sun, S., Ren, T., Li, X., Cao, X., Gao, J. (2020) Polyunsaturated fatty acids synthesized by freshwater fish: A new insight to the roles of elovl2 and elovl5 in vivo. Biochemical and Biophysical Research Communications. 532(3):414-419
- Unal Eroglu, A., Mulligan, T.S., Zhang, L., White, D.T., Sengupta, S., Nie, C., Lu, N.Y., Qian, J., Xu, L., Pei, W., Burgess, S.M., Saxena, M.T., Mumm, J.S. (2018) Multiplexed CRISPR/Cas9 Targeting of Genes Implicated in Retinal Regeneration and Degeneration. Frontiers in cell and developmental biology. 6:88
- Oboh, A., Navarro, J.C., Tocher, D.R., Monroig, O. (2017) Elongation of very Long-Chain (>C24) Fatty Acids in Clarias gariepinus: Cloning, Functional Characterization and Tissue Expression of elovl4 Elongases.. Lipids. 52(10):837-848
1 - 10 of 20
Show