Gene
wasb
- ID
- ZDB-GENE-030131-7098
- Name
- WASP actin nucleation promoting factor b
- Symbol
- wasb Nomenclature History
- Previous Names
-
- was
- wasp1 (1)
- wu:fk81c08
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable small GTPase binding activity. Acts upstream of or within leukocyte chemotaxis; myoblast fusion; and regulation of neutrophil migration. Predicted to be located in cytoskeleton and nucleus. Predicted to be active in cytoplasm. Is expressed in hematopoietic system; leukocyte; neuromast; thrombocyte; and thymus. Used to study Wiskott-Aldrich syndrome. Human ortholog(s) of this gene implicated in Wiskott-Aldrich syndrome; X-linked severe congenital neutropenia; and thrombocytopenia. Orthologous to human WAS (WASP actin nucleation promoting factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:64164 (2 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hu3279 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| hu3280 | Allele with one point mutation | Unknown | Unknown | ENU | |
| sa1001 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa16049 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa34392 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sw113 | Allele with one delins | Exon 1 | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-wasb | Luo et al., 2022 | |
| CRISPR2-wasb | Luo et al., 2022 | |
| CRISPR3-wasb | Rosa et al., 2021 | |
| MO1-wasb | N/A | (3) |
| MO2-wasb | N/A | Cvejic et al., 2008 |
| MO3-wasb | N/A | Rounioja et al., 2012 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| thrombocytopenia | Alliance | Thrombocytopenia, X-linked | 313900 |
| thrombocytopenia | Alliance | Thrombocytopenia, X-linked, intermittent | 313900 |
| Wiskott-Aldrich syndrome | Alliance | Wiskott-Aldrich syndrome | 301000 |
| X-linked severe congenital neutropenia | Alliance | Neutropenia, severe congenital, X-linked | 300299 |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| Wiskott-Aldrich syndrome | wasbhu3280/hu3280 | standard conditions | Jones et al., 2013 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Actin nucleation-promoting factor WAS, C-terminal | CRIB domain | CRIB domain superfamily | PH-like domain superfamily | WASP family, EVH1 domain | WH1/EVH1 domain | WH2 domain |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7T318 | InterPro | 479 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-233C3 | ZFIN Curated Data | |
| Encodes | EST | fk81c08 | ||
| Encodes | cDNA | MGC:64164 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199938 (1) | 1748 nt | ||
| Genomic | GenBank:BX248384 (1) | 155293 nt | ||
| Polypeptide | UniProtKB:Q7T318 (1) | 479 aa |
- Li, M., Wang, R., Yan, T., Tao, X., Gao, S., Wang, Z., Chai, Y., Qiu, S., Chen, W. (2024) Dual effects of DLG5 (disks large homolog 5 gene) modulation on chemotherapy-induced thrombocytopenia and nausea/vomiting via the hippo signalling pathway. British journal of pharmacology. 182(4):1090-1106
- Luo, Z., Shi, J., Pandey, P., Ruan, Z.R., Sevdali, M., Bu, Y., Lu, Y., Du, S., Chen, E.H. (2022) The cellular architecture and molecular determinants of the zebrafish fusogenic synapse. Developmental Cell. 57(13):1582-1597.e6
- Rosa, A., Giese, W., Meier, K., Alt, S., Klaus-Bergmann, A., Edgar, L.T., Bartels, E., Collins, R., Szymborska, A., Coxam, B., Bernabeu, M.O., Gerhardt, H. (2021) Wasp controls oriented migration of endothelial cells to achieve functional vascular patterning. Development (Cambridge, England). 149(3):
- Jerison, E.R., Quake, S.R. (2020) Heterogeneous T cell motility behaviors emerge from a coupling between speed and turning in vivo. eLIFE. 9:
- He, Z., Crenshaw, E., Raper, J.A. (2019) Semaphorin/neuropilin binding specificities are stable over 400 million years of evolution. Biochemical and Biophysical Research Communications. 517(1):23-28
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Jones, R.A., Feng, Y., Worth, A.J., Thrasher, A.J., Burns, S.O., and Martin, P. (2013) Modelling human Wiskott-Aldrich syndrome protein mutants in zebrafish larvae using live in vivo imaging. Journal of Cell Science. 126(Pt 18):4077-84
- Ma, D., Wang, L., Wang, S., Gao, Y., Wei, Y., and Liu, F. (2012) Foxn1 maintains thymic epithelial cells to support T-cell development via mcm2 in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 109(51):21040-21045
- Rounioja, S., Saralahti, A., Rantala, L., Parikka, M., Henriques-Normark, B., Silvennoinen, O., and Rämet, M. (2012) Defense of zebrafish embryos against Streptococcus pneumoniae infection is dependent on the phagocytic activity of leukocytes. Developmental and comparative immunology. 36(2):342-8
- Lindeman, L.C., Andersen, I.S., Reiner, A.H., Li, N., Aanes, H., Ostrup, O., Winata, C., Mathavan, S., Muller, F., Aleström, P., and Collas, P. (2011) Prepatterning of Developmental Gene Expression by Modified Histones before Zygotic Genome Activation. Developmental Cell. 21(6):993-1004
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