Gene
col10a1b
- ID
- ZDB-GENE-030131-7079
- Name
- collagen, type X, alpha 1b
- Symbol
- col10a1b Nomenclature History
- Previous Names
-
- wu:fk76c08 (1)
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to be an extracellular matrix structural constituent conferring tensile strength. Predicted to be involved in glomerular basement membrane development. Predicted to be located in extracellular region. Predicted to be part of collagen trimer. Predicted to be active in extracellular matrix. Is expressed in ceratobranchial 5 tooth; dental papilla; and regenerating fin. Human ortholog(s) of this gene implicated in Schmid metaphyseal chondrodysplasia and osteochondrodysplasia. Orthologous to human COL10A1 (collagen type X alpha 1 chain).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Schmid metaphyseal chondrodysplasia | Alliance | Metaphyseal chondrodysplasia, Schmid type | 156500 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | C1q domain | Collagen/C1q domain-containing | Collagen triple helix repeat | Tumour necrosis factor-like domain superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:A0A0R4IAT5 | InterPro | 659 |
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- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
col10a1b-201
(1)
|
Ensembl | 2,356 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
- Park, S.J., Silic, M.R., Staab, P.L., Chen, J., Zackschewski, E.L., Zhang, G. (2024) Evolution of two-pore domain potassium channels and their gene expression in zebrafish embryos. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(8):722-749
- Chang, S.H., Giong, H.K., Kim, D.Y., Kim, S., Oh, S., Yun, U.J., Lee, J.S., Park, K.W. (2023) Activation of Nrf2 by sulfuretin stimulates chondrocyte differentiation and increases bone lengths in zebrafish. BMB reports. 56:496501496-501
- Debiais-Thibaud, M., Simion, P., Ventéo, S., Muñoz, D., Marcellini, S., Mazan, S., Haitina, T. (2019) Skeletal mineralisation in association with type X collagen expression is an ancestral feature for jawed vertebrates. Molecular Biology and Evolution. 36(10):2265-2276
- Bretaud, S., Nauroy, P., Malbouyres, M., Ruggiero, F. (2018) FISHING FOR COLLAGEN FUNCTION: ABOUT DEVELOPMENT, REGENERATION AND DISEASE. Seminars in cell & developmental biology. 89:100-108
- Ton, Q.V., and Iovine, M.K. (2013) Identification of an evx1-Dependent Joint-Formation Pathway during FIN Regeneration. PLoS One. 8(11):e81240
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