Gene

rapgef2b

ID
ZDB-GENE-030131-6959
Name
Rap guanine nucleotide exchange factor 2b
Symbol
rapgef2b Nomenclature History
Previous Names
  • rapgef2
  • fa11h07
  • wu:fa11h07
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to have GTPase activator activity and Rap guanyl-nucleotide exchange factor activity. Predicted to be involved in positive regulation of GTPase activity; regulation of cell population proliferation; and small GTPase mediated signal transduction. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 7. Orthologous to human RAPGEF2 (Rap guanine nucleotide exchange factor 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Ebarasi et al., 2009
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With rapgef2b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
familial adult myoclonic epilepsy 7 Alliance ?Epilepsy, familial adult myoclonic, 7 618075
Associated With rapgef2b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000159 Ras-associating domain
Domain IPR000595 Cyclic nucleotide-binding domain
Domain IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
Domain IPR001478 PDZ domain
Domain IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
Domain IPR008915 Peptidase M50
Homologous_superfamily IPR014710 RmlC-like jelly roll fold
Homologous_superfamily IPR018490 Cyclic nucleotide-binding domain superfamily
Homologous_superfamily IPR023578 Ras guanine nucleotide exchange factor domain superfamily
Homologous_superfamily IPR029071 Ubiquitin-like domain superfamily
Homologous_superfamily IPR036034 PDZ superfamily
Homologous_superfamily IPR036964 Ras guanine-nucleotide exchange factor, catalytic domain superfamily
Domain Details Per Protein
Protein Length Cyclic nucleotide-binding domain Cyclic nucleotide-binding domain superfamily PDZ domain PDZ superfamily Peptidase M50 Ras-associating domain Ras guanine-nucleotide exchange factor, catalytic domain superfamily Ras guanine nucleotide exchange factor domain superfamily Ras guanine-nucleotide exchange factors catalytic domain Ras-like guanine nucleotide exchange factor, N-terminal RmlC-like jelly roll fold Ubiquitin-like domain superfamily
UniProtKB:A0A2R8QLQ3 1607
UniProtKB:A0A8M3ASA2 1538
UniProtKB:A0A8M6Z2S8 1629
UniProtKB:A0A8M6Z9Y2 1626
UniProtKB:A0A8M6Z291 1473
UniProtKB:A0A8M6Z9Y5 1518
UniProtKB:A0A8M6Z4A7 1601
UniProtKB:A0A8M6Z2T1 1604
UniProtKB:A0A8M6Z9J4 1634
UniProtKB:A0A0R4IBW6 1618
UniProtKB:A0A8M6Z4A2 1628
UniProtKB:A0A8M6Z286 1612
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations