ZFIN is now using GRCz12tu for Genomic Data
Gene
ddx46
- ID
- ZDB-GENE-030131-667
- Name
- DEAD (Asp-Glu-Ala-Asp) box polypeptide 46
- Symbol
- ddx46 Nomenclature History
- Previous Names
-
- fb39a03
- fj67d06
- wu:fb39a03 (1)
- wu:fj67d06
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and ATP-dependent activity, acting on DNA. Acts upstream of or within several processes, including digestive system development; liver morphogenesis; and positive regulation of cell differentiation. Predicted to be located in Cajal body and nuclear speck. Predicted to be part of U2-type spliceosomal complex. Predicted to be active in nucleus. Is expressed in brain; digestive system; head; hematopoietic system; and pectoral fin bud. Orthologous to human DDX46 (DEAD-box helicase 46).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 14 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR000629 | ATP-dependent RNA helicase DEAD-box, conserved site |
| Domain | IPR001650 | Helicase, C-terminal domain-like |
| Domain | IPR011545 | DEAD/DEAH box helicase domain |
| Domain | IPR014001 | Helicase superfamily 1/2, ATP-binding domain |
| Domain | IPR014014 | RNA helicase, DEAD-box type, Q motif |
| Domain | IPR056149 | ATP-dependent RNA helicase PRP5/DDX46/KHDC4, KH domain |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
| Protein | Additional Resources | Length | ATP-dependent RNA helicase DEAD-box, conserved site | ATP-dependent RNA helicase PRP5/DDX46/KHDC4, KH domain | DEAD/DEAH box helicase domain | Helicase, C-terminal domain-like | Helicase superfamily 1/2, ATP-binding domain | P-loop containing nucleoside triphosphate hydrolase | RNA helicase, DEAD-box type, Q motif |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q4TVV3 | InterPro | 1018 | |||||||
| UniProtKB:A0A8M3AX96 | InterPro | 1035 | |||||||
| UniProtKB:A0AB32TD48 | InterPro | 1034 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers