Gene
ubr5
- ID
- ZDB-GENE-030131-6559
- Name
- ubiquitin protein ligase E3 component n-recognin 5
- Symbol
- ubr5 Nomenclature History
- Previous Names
-
- edd1 (1)
- wu:fa16c12
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable ubiquitin-ubiquitin ligase activity. Predicted to be involved in positive regulation of canonical Wnt signaling pathway and protein polyubiquitination. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in breast cancer (multiple) and carcinoma (multiple). Orthologous to human UBR5 (ubiquitin protein ligase E3 component n-recognin 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| chb24 | Allele with one deletion | Exon 5 | Unknown | CRISPR | |
| la012990Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la019848Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa17638 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa22957 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa22958 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa22959 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa36264 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa36265 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000569 | HECT domain |
| Domain | IPR002004 | Polyadenylate-binding protein/Hyperplastic disc protein, C-terminal |
| Domain | IPR003126 | Zinc finger, UBR-type |
| Domain | IPR024725 | E3 ubiquitin-protein ligase UBR5, ubiquitin-associated domain |
| Domain | IPR047503 | E3 ubiquitin-protein ligase UBR5, UBR-box |
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Domain Details Per Protein
| Protein | Additional Resources | Length | E3 ubiquitin-protein ligase UBR5, ubiquitin-associated domain | E3 ubiquitin-protein ligase UBR5, UBR-box | HECT domain | HECT, E3 ligase catalytic domain | PABC (PABP) domain | Polyadenylate-binding protein/Hyperplastic disc protein, C-terminal | Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II | Zinc finger, UBR-type |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9P7S4 | InterPro | 2828 | ||||||||
| UniProtKB:A0A8M1NV16 | InterPro | 2794 | ||||||||
| UniProtKB:A0A8M9PJ96 | InterPro | 2833 | ||||||||
| UniProtKB:A0A8M2B4T2 | InterPro | 2816 | ||||||||
| UniProtKB:A0A8M9NZ45 | InterPro | 2832 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-135D14 | ZFIN Curated Data | |
| Encodes | EST | fa16c12 | ||
| Encodes | EST | IMAGE:6963255 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001164394 (1) | 8901 nt | ||
| Genomic | GenBank:CR293507 (2) | 178271 nt | ||
| Polypeptide | UniProtKB:A0A8M9PJ96 (1) | 2833 aa |
- LaCoursiere, C.M., Ullmann, J.F.P., Koh, H.Y., Turner, L., Baker, C.M., Robens, B., Shao, W., Rotenberg, A., McGraw, C.M., Poduri, A.H. (2024) Zebrafish models of candidate human epilepsy-associated genes provide evidence of hyperexcitability. iScience. 27:110172110172
- Li, F., Wang, H., Liu, J., Lin, J., Zeng, A., Ai, W., Wang, X., Dahlgren, R.A., Wang, H. (2016) Immunotoxicity of β-Diketone Antibiotic Mixtures to Zebrafish (Danio rerio) by Transcriptome Analysis. PLoS One. 11:e0152530
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Liu, C., Song, G., Mao, L., Long, Y., Li, Q., Cui, Z. (2015) Generation of an Enhancer-Trapping Vector for Insertional Mutagenesis in Zebrafish. PLoS One. 10:e0139612
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
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