heatr1

ID

ZDB-GENE-030131-6378

Name

HEAT repeat containing 1

Symbol

heatr1 Nomenclature History

Previous Names

BAP28-like (1)
fi69e12
flj10359 (1)
wu:fi69e12
zgc:63510

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable snoRNA binding activity. Acts upstream of or within maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); negative regulation of apoptotic process; and regulation of RNA stability. Predicted to be located in nucleolus. Predicted to be part of 90S preribosome; small-subunit processome; and t-UTP complex. Is expressed in eye; forebrain; immature eye; midbrain; and midbrain hindbrain boundary. Human ortholog(s) of this gene implicated in pancreatic ductal carcinoma. Orthologous to human HEATR1 (HEAT repeat containing 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Azuma et al., 2006

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With heatr1 Human Ortholog

No data available

Associated With heatr1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR012954	BP28, C-terminal domain
Domain	IPR022125	U3 small nucleolar RNA-associated protein 10, N-terminal
Domain	IPR056473	Utp10/HEAT1, HEAT-repeats domain
Family	IPR040191	U3 small nucleolar RNA-associated protein 10
Homologous_superfamily	IPR011989	Armadillo-like helical
Homologous_superfamily	IPR016024	Armadillo-type fold