ZFIN is now using GRCz12tu for Genomic Data
Gene
ldhd
- ID
- ZDB-GENE-030131-6140
- Name
- lactate dehydrogenase D
- Symbol
- ldhd Nomenclature History
- Previous Names
-
- wu:fi36b04
- zgc:55447
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables (2R)-2-hydroxycarboxylate dehydrogenase activity and D-lactate dehydrogenase (FAD) activity. Involved in lactate catabolic process. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in inherited metabolic disorder. Orthologous to human LDHD (lactate dehydrogenase D).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55447 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Monroe et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| D-lactic aciduria with susceptibility to gout | 245450 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004113 | FAD-binding oxidoreductase/transferase, type 4, C-terminal |
| Domain | IPR006094 | FAD linked oxidase, N-terminal |
| Domain | IPR016166 | FAD-binding domain, PCMH-type |
| Homologous_superfamily | IPR016164 | FAD-linked oxidase-like, C-terminal |
| Homologous_superfamily | IPR016169 | FAD-binding, type PCMH, subdomain 2 |
| Homologous_superfamily | IPR016171 | Vanillyl-alcohol oxidase, C-terminal subdomain 2 |
| Homologous_superfamily | IPR036318 | FAD-binding, type PCMH-like superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | FAD-binding domain, PCMH-type | FAD-binding oxidoreductase/transferase, type 4, C-terminal | FAD-binding, type PCMH-like superfamily | FAD-binding, type PCMH, subdomain 2 | FAD-linked oxidase-like, C-terminal | FAD linked oxidase, N-terminal | Vanillyl-alcohol oxidase, C-terminal subdomain 2 |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1QXM5 | InterPro | 497 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers