Gene

plk3

ID

ZDB-GENE-030131-6134

Name

polo-like kinase 3 (Drosophila)

Symbol

plk3 Nomenclature History

Previous Names

cnk (1)
wu:fi35f10

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including Golgi disassembly; mitotic G1/S transition checkpoint signaling; and mitotic spindle organization. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in Golgi apparatus and nucleolus. Predicted to be active in several cellular components, including kinetochore; microtubule cytoskeleton; and nucleus. Is expressed in liver; spinal cord; and spleen. Orthologous to human PLK3 (polo like kinase 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7144737 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With plk3 Human Ortholog

No data available

Associated With plk3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR000959	POLO box domain
Domain	IPR033695	Second polo-box domain
Domain	IPR033701	First polo-box domain
Domain	IPR042703	Serine/threonine-protein kinase PLK3, catalytic domain
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR036947	POLO box domain superfamily