Gene

ankle2

ID
ZDB-GENE-030131-6090
Name
ankyrin repeat and LEM domain containing 2
Symbol
ankle2 Nomenclature History
Previous Names
  • fi34a12
  • si:dkey-215k6.5
  • wu:fi34a12
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to have protein phosphatase 2A binding activity. Predicted to be involved in mitotic nuclear envelope reassembly; negative regulation of phosphorylation; and positive regulation of protein dephosphorylation. Predicted to localize to endoplasmic reticulum. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 16. Orthologous to human ANKLE2 (ankyrin repeat and LEM domain containing 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from Apridita Sebastian et al., 2022
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ankle2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
primary autosomal recessive microcephaly 16 Alliance Microcephaly 16, primary, autosomal recessive 616681
Associated With ankle2 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003887 LEM domain
Domain IPR011320 Ribonuclease H1, N-terminal
Domain IPR035006 Ankyrin repeat and LEM domain-containing protein 2, LEM domain
Homologous_superfamily IPR011015 LEM/LEM-like domain superfamily
Homologous_superfamily IPR036770 Ankyrin repeat-containing domain superfamily
Homologous_superfamily IPR037056 Ribonuclease H1, N-terminal domain superfamily
Repeat IPR002110 Ankyrin repeat
Domain Details Per Protein
Protein Length Ankyrin repeat Ankyrin repeat and LEM domain-containing protein 2, LEM domain Ankyrin repeat-containing domain superfamily LEM domain LEM/LEM-like domain superfamily Ribonuclease H1, N-terminal Ribonuclease H1, N-terminal domain superfamily
UniProtKB:A2CEB2 961
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations